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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 17巻2号
  1. 部局別インデックス
  2. その他

[原著]Expression of interleukin-7 in the model of orthotopic liver transplantation in rats

http://hdl.handle.net/20.500.12000/0002016087
http://hdl.handle.net/20.500.12000/0002016087
c1e688a5-625f-4ec5-8532-47222045fe16
名前 / ファイル ライセンス アクション
v17p79.pdf v17p79.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]Expression of interleukin-7 in the model of orthotopic liver transplantation in rats
言語 ja
作成者 Shiraishi, Masayuki

× Shiraishi, Masayuki

en Shiraishi, Masayuki

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Kusano, Toshiomi

× Kusano, Toshiomi

en Kusano, Toshiomi

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Hara, Junji

× Hara, Junji

en Hara, Junji

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Hiroyasu, Shungo

× Hiroyasu, Shungo

en Hiroyasu, Shungo

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Miyaguni, Takao

× Miyaguni, Takao

en Miyaguni, Takao

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Ma, Shao-Ping

× Ma, Shao-Ping

en Ma, Shao-Ping

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Muto, Yoshihiro

× Muto, Yoshihiro

en Muto, Yoshihiro

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 interleukin-7
主題
言語 en
主題Scheme Other
主題 liver transplantation
主題
言語 en
主題Scheme Other
主題 acute rejection
主題
言語 en
主題Scheme Other
主題 thymus
内容記述
内容記述タイプ Other
内容記述 The purpose of this experiment was to determine whether interleukin-7 (IL-7) is involved in the development of acute liver rejection in the model of orthotopic liver transplantation in rats. We evaluated IL-7 expression using samples serially obtained from the various organs, on 1, 3, 5, 7, 10 post-operative day (POD, n=5 at each POD) in two groups: Group I --BN (RT1^n) to BN rats; Group II --DA (RTl^a) to BN rats. IL-7 gene sequence and IL-7 mRNA were detected with PCR and Northern blotting. IL-7 levels were determined with enzyme-linked immunosorbent assay (ELISA), and data were expressed as $mean \pm standard$ error. Group I animals (n=5) survived indefinitely. Whereas group II animals (n=5) died within $12.8 \pm 2.7$ days due to the acute rejection proved histologically. In both groups, IL-7 gene sequence could be detected in every organ examined by PCR. In Northern blotting, IL-7 mRNA could be detected in lOO% of thymic and bone marrow samples, and one third ofthekidney in both groups. In ELISA, IL-7 levels of group I remained low throughout the experiment in each organ, whereas in group II, IL-7 levels increased until POD 10, with statisticaly significant differences against those in group I on POD 10, in the serum, liver and thymus (p<0.05) (serum--$3.60 \pm 0.39$ vs. $0.63 \pm 0.09$, liver--$7.29 \pm 1.4$ vs. $2.66 \pm 0.38$, thymus--$13.3 \pm 5.8$ vs. $0.91 \pm 0.32$). In conclusion, IL-7 was increasingly produced in the thymus during the acute rejection of the graft liver. The thymus and its IL-7 are thought to be playing an important role in the acute rejection of the graft liver.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
出版者
言語 en
出版者 Ryukyu Medical Association
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 17, 号 2, p. 79-84, 発行日 1997
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