{"_buckets": {"deposit": "6bebf237-5c3a-49c1-9713-e47cef4082ac"}, "_deposit": {"id": "2016087", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2016087"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02016087", "sets": ["1642838210080", "1642838412624"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "[原著］Expression of interleukin-7 in the model of orthotopic liver transplantation in rats", "subitem_1551255648112": "ja"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shiraishi, Masayuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kusano, Toshiomi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hara, Junji", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hiroyasu, Shungo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Miyaguni, Takao", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ma, Shao-Ping", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Muto, Yoshihiro", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "琉球医学会"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "interleukin-7"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "liver transplantation"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "acute rejection"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "thymus"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "The purpose of this experiment was to determine whether interleukin-7 (IL-7) is involved in the development of acute liver rejection in the model of orthotopic liver transplantation in rats. We evaluated IL-7 expression using samples serially obtained from the various organs, on 1, 3, 5, 7, 10 post-operative day (POD, n=5 at each POD) in two groups: Group I --BN (RT1^n) to BN rats; Group II --DA (RTl^a) to BN rats. IL-7 gene sequence and IL-7 mRNA were detected with PCR and Northern blotting. IL-7 levels were determined with enzyme-linked immunosorbent assay (ELISA), and data were expressed as $mean \\pm standard$ error. Group I animals (n=5) survived indefinitely. Whereas group II animals (n=5) died within $12.8 \\pm 2.7$ days due to the acute rejection proved histologically. In both groups, IL-7 gene sequence could be detected in every organ examined by PCR. In Northern blotting, IL-7 mRNA could be detected in lOO% of thymic and bone marrow samples, and one third ofthekidney in both groups. In ELISA, IL-7 levels of group I remained low throughout the experiment in each organ, whereas in group II, IL-7 levels increased until POD 10, with statisticaly significant differences against those in group I on POD 10, in the serum, liver and thymus (p\u003c0.05) (serum--$3.60 \\pm 0.39$ vs. $0.63 \\pm 0.09$, liver--$7.29 \\pm 1.4$ vs. $2.66 \\pm 0.38$, thymus--$13.3 \\pm 5.8$ vs. $0.91 \\pm 0.32$). In conclusion, IL-7 was increasingly produced in the thymus during the acute rejection of the graft liver. The thymus and its IL-7 are thought to be playing an important role in the acute rejection of the graft liver.", "subitem_description_type": "Other"}, {"subitem_description": "論文", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "琉球医学会"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "Ryukyu Medical Association"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1346888X"}, {"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0289-1530"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN10369445"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "琉球医学会誌 = Ryukyu Medical Journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1997", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "84", "bibliographicPageStart": "79", "bibliographicVolumeNumber": "17"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "v17p79.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2016087/files/v17p79.pdf"}, "version_id": "118ef2f9-c2e6-4fea-aa4a-261bd514a29c"}]}, "item_title": "[原著］Expression of interleukin-7 in the model of orthotopic liver transplantation in rats", "item_type_id": "15", "owner": "1", "path": ["1642838210080", "1642838412624"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002016087", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-07-02"}, "publish_date": "2010-07-02", "publish_status": "0", "recid": "2016087", "relation": {}, "relation_version_is_last": true, "title": ["[原著］Expression of interleukin-7 in the model of orthotopic liver transplantation in rats"], "weko_shared_id": -1}