@article{oai:u-ryukyu.repo.nii.ac.jp:02016090, author = {島尻, 佳典 and 砂川, 優 and 高須, 信行 and Shimajiri, Yoshinori and Sunakawa, Suguru and Takasu, Nobuyuki}, issue = {3}, journal = {琉球医学会誌 = Ryukyu Medical Journal}, month = {}, note = {Diabetes mellitus is a hyperglycemic state due to absolute or relative insulin deficiency. Adequate treatment is required to prevent diabetic complications; neuropathy, retinopathy and nephropathy. Adequate treatment is also required to prevent macroangiopathy, such as brain infarction, myocardial infarction and arteriosclerosis obliterans. In Japan, prevalence of diabetes mellitus has been estimated to be more than 6 million. Complications of the disease inhibit patients' quality of life. Early diagnosis and treatment are important not only for the patients, but also for the society. For the above reasons, we chose this topic and discuss how we manage diabetic patients in our department by presenting some experimental data. Diabetes mellitus is clinically classified as 1) insulin dependent diabetes mellitus: IDDM, 2) non-insulin dependent diabetes mellitus: NIDDM, 3) gestational diabetes mellitus and 4) others. We diagnose diabetes mellitus based on the criteria given by the Japan Diabetes Society. GAD_65 antibody is helpful for the differential diagnosis of IDDM and NIDDM. HbA_1c and 1,5 anhydroglucitol are useful markers for following diabetic patients. Steady-state plasma glucose method instead of glucose clump technique is valuable for evaluation of insulin resistance. We evaluate neuropathy by nerve conduction velocity and evaluate autonomic neuropathy by CV_R.R and Schellong test. Evaluation for retinopathy is based on Fukuda's classification and that for nephropathy is based on the Japanese Ministry of Public Health and Welfare classification. Treatment of IDDM, including diabetic ketoacidosis, is to supply sufficient insulin, $ \alpha $ -glucosidase inhibitors, sulfonylureas and insulin resistance reducing agents are useful drugs in treating NIDDM. The aim of the diabetic treatment is to lmprove the progressing complications. It is important to connect diagnosis and treatment directly., 論文}, pages = {169--174}, title = {[話題]琉球大学医学部第二内科における糖尿病の診断と治療}, volume = {17}, year = {1997} }