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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 17巻2号
  1. 部局別インデックス
  2. その他

[原著]Genetic influence of HLA-DR on longevity in Okinawan people

http://hdl.handle.net/20.500.12000/0002016117
http://hdl.handle.net/20.500.12000/0002016117
36d56836-f48a-4c36-b960-854e575f8e7d
名前 / ファイル ライセンス アクション
v17p85.pdf v17p85.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]Genetic influence of HLA-DR on longevity in Okinawan people
言語 ja
作成者 Akisaka, Masafumi

× Akisaka, Masafumi

en Akisaka, Masafumi

Suzuki, Makoto

× Suzuki, Makoto

en Suzuki, Makoto

Inoko, Hidetoshi

× Inoko, Hidetoshi

en Inoko, Hidetoshi

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 centenarian
言語 en
主題Scheme Other
主題 HLA-DR
言語 en
主題Scheme Other
主題 longevity
言語 en
主題Scheme Other
主題 genetics
言語 en
主題Scheme Other
主題 Okinawa
内容記述
内容記述タイプ Other
内容記述 Okinawa is well-known as one of the longevity areas in the world and the population rate of centenarians is higher by far than that of the whole of Japan. However, only few reports have used genetic approaches to explain Okinawan long lifespan. In this study, we analyzed human luekocyte antigen (HLA) both in phenotyping and in genotyping for the same subjects of Okinawan centenarians and normal adults for the purpose of clarifying one of the primary genetic factors in major histo-compatibility complex (MHC) region genes associated with longevity. Eighty-six healthy centenarians and 142 normal adults in Okinawa were studied. For HLA phenotyping, 14 antigen specificities on DR locus were typed according to the standard microdroplet lymphocyte cytotoxicity test, and for genotyping 27 alleles on DRBl were typed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method based on the digestion of PCR-amplified DNAs with allele specific enzymes. In the present study, DR1 was found to be high in centenarians in phenotyping (P=0.029, RR=5.779), which was similar in genotypeing (DRB1^*0101: P=0.030, RR=5.779), but both results were not significantly different at Pc level. However, DRB1^*1401 (P=0.00103, Pc=0.028, RR-3.456) was significantly high. These data suggest that several alleles of HLA-DRB1, such as DRB1^*1401, favourably relate to longevity.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 17, 号 2, p. 85-88
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