@article{oai:u-ryukyu.repo.nii.ac.jp:02016131, author = {Shimoji, Hideaki and Nishimaki, Tadashi and Sunagawa, Hiroki and Kuninaka, Kouichi and Matsubara, Hirotaka}, issue = {1-2}, journal = {琉球医学会誌 = Ryukyu Medical Journal}, month = {}, note = {PURPOSE: The aim of this study was to assess the efficacy and safety of combination chemotherapy with docetaxel and TS-1. PATIENTS AND METHODS: Five patients with advanced gastric cancer were treated with a combination chemotherapy regimen consisting of docetaxel and TS-1. All patients had undergone prior chemotherapy. Docetaxel at a dose of 30 mg/m^2 was intravenously administered on Day 1 and 8, and TS-1 at a dose of 80mg/m^2 /day was orally administered for 2 weeks followed by 1 drug-free week. RESULTS: Three of the 5 patients showed a partial response, of a response rate of 60%. Two of the 5 patients had stable diseases. One patient experienced grade 3 leukocytopeniia, grade 2 diarrhea and grade 2 alopecia. In the other patients, only low grade toxicities (grade 1 or 2 leukocytopenia, neutrocytopenia and anemia) were seen. CONCLUSION: The combination chemotherapy of docetaxel and TS-1 was found to be effective and well tolerable by advanced gastric cancer patients. This combination may be useful as a second-line chemotherapy., 論文}, pages = {21--24}, title = {[原著]A pilot study of docetaxel and TS-1 combination chemotherapy for advanced gastric cancer}, volume = {23}, year = {2004} }