{"created":"2022-02-22T04:15:20.113677+00:00","id":2016149,"links":{},"metadata":{"_buckets":{"deposit":"16032d8c-e343-415b-b235-fb51b41052fb"},"_deposit":{"id":"2016149","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2016149"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02016149","sets":["1642838163960:1642838198944:1642838199408:1642838217169","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[原著］Distribution of Reduced Expression of E-Cadherin and Catenins in Squamous Cell Carcinoma of the Tongue with Special Reference to Its Clinical Significance","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kiyuna, Junko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hiratsuka, Hiroyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamori, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sunakawa, Hajime","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"E-cadherin"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Catenins"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Lymph node metastasis"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Squamous cell carcinoma of the tongue"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The biologic aggressiveness of squamous cell carcinoma of the tongue is reflected in its ability to metastasize to cervical lymph nodes. Aberrant expression of E-cadherin and/or catenins is known to be associated with invasiveness and metastasis in a number of different cancer types but distributions of E-cadherin and catenins expression are unclear. Furthermore concerning squamous cell carcinoma of the tongue, the clinical significance of expression patterns has not been adequately investigated. In the current study, membranous expression of E-cadherin and catenins ( $ \\alpha $, $ \\beta $ , and $ \\gamma $) at the superficial to middle part and the peripheral invading front of the tumor were evaluated in 79 patients with squamous cell carcinoma of the tongue by immunohistochemical methods using monoclonal antibodies. Both E-cadherin and catenins membranous expression was more preserved in the superficial to middle part of the tumor than in the peripheral invading front (p=0.0007, =0.0001, <0.0001, and <0.0001, respectively). Univariate analysis revealed that reduced membranous expression of E-cadherin, $ \\beta $-catenin, and $ \\gamma $-catenin at the invading front of the tumor showed significant reverse correlation with the T classification of the primary tumors (p=0.02, =0.02, and =0.03, respectively), and that reduced membranous expression of E-cadherin and $ \\gamma $-catenin was correlated with the clinical stage (p=0.01 and =0.04, respectively). In addition, reduced membranous expression of E-cadherin, $ \\alpha $-catenin, $ \\beta $-catenin, and $ \\gamma $-catenin also showed a significant correlation witht he mode of carcinoma invasion (p=0.008, =0.01, =0.02, and, =0.02, respectively). Moreover, reduced expression of E-cadherin, $ \\alpha $-catenin, $ \\beta $-catenin, and $ \\gamma $-catenin was significantly associated with postsurgical lymph node metastasis (p<0.0001, =0.007, =0.02, and =0.001, respectively). Multivariate analysis revealed that the combined evaluation of reduction or loss of Ecadherin and/or $ \\gamma $-catenin membranous expression was the independent predictor for cervical lymph node metastasis (relative risk; 13.5) in patients with squamous cell carcinoma of the tongue. These results suggested that the assessment of E-cadherin and $ \\gamma $-catenin membranous expression at the peripheral invading front of the tumor could be clinically useful, especially for selecting patients who require neck dissection.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"27","bibliographicPageStart":"19","bibliographicVolumeNumber":"21"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v21p19.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2016149/files/v21p19.pdf"},"version_id":"95d2e1d2-bdc5-4b9d-b81a-20f87abe2c88"}]},"item_title":"[原著］Distribution of Reduced Expression of E-Cadherin and Catenins in Squamous Cell Carcinoma of the Tongue with Special Reference to Its Clinical Significance","item_type_id":"15","owner":"1","path":["1642838217169","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2016149","relation_version_is_last":true,"title":["[原著］Distribution of Reduced Expression of E-Cadherin and Catenins in Squamous Cell Carcinoma of the Tongue with Special Reference to Its Clinical Significance"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:51:21.549555+00:00"}