{"created":"2022-02-22T04:15:32.161371+00:00","id":2016156,"links":{},"metadata":{"_buckets":{"deposit":"730af65f-43d4-401d-9ab9-95ca8bef4b3c"},"_deposit":{"id":"2016156","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2016156"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02016156","sets":["1642838163960:1642838198944:1642838199408:1642838214651","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[総説］Cytometrical and morphologic heterogeneity in cell cycle-phased nuclei in a single glioma","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshii, Yoshihiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Saito, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tsurushima, Hideo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hyodo, Akio","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"human gliomas"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"G2M phase cell"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"densitometry"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"morphometry"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"We examined nuclear morphometry and DNA content in SG2M phase tumor cells (including S phase and G2M phase cells) using image analysis to know whether or not cytometrical heterogeneity is always coupled with morphologic heterogeneity in 48 adult patients with glioma whose clinical follow-up was obtained. The SG2M phase cells were defined as the cells with a value (SD+0.1) above the mean diploid DNA indices. An estimated DNA index of the G2M phase cells (estimated G2M DNA index) was by multiplying the average G0G1 DNA indices by two. The G2M ploidy of each patient wasclassified into three patterns based on the difference between the mean SG2M DNA index and the estimated G2M DNA index: hypotetraploidy, tetraploidy or hypertetraploidy. Patients with G2M-hypertetraploid high grade gliomas had a significantly shorter time to tumor progression than patients with G2M-tetraploid tumors. The nuclear size of SG2M phase cells was larger and the nuclear shape was more markedly deformed than in G0G1 phase cells. However, there was no significant difference in the nuclear area or form factor in the SG2M nuclei between G2M-hypertetraploid and G2M-tetraploid cells with high grade glioma, high grade and low grade gliomas with G2M-tetraploid cell. Our results suggest that cytometrical heterogeneity does not always correlate with morphologic heterogeneity in glioma cells and that glioma cells with giant, multinucleated, or bizzare nuclei may have low proliferative potential.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"192","bibliographicPageStart":"187","bibliographicVolumeNumber":"19"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v19p187.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2016156/files/v19p187.pdf"},"version_id":"ecd3a656-6417-4950-a0cd-b5ec1e67c1a1"}]},"item_title":"[総説］Cytometrical and morphologic heterogeneity in cell cycle-phased nuclei in a single glioma","item_type_id":"15","owner":"1","path":["1642838214651","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2016156","relation_version_is_last":true,"title":["[総説］Cytometrical and morphologic heterogeneity in cell cycle-phased nuclei in a single glioma"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:51:29.389377+00:00"}