ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "3e044463-b846-4564-b404-d8def334e014"}, "_deposit": {"id": "2016158", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2016158"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02016158", "sets": ["1642838214651", "1642838412624"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "[\u7dcf\u8aac\uff3d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u6210\u9577\u56e0\u5b50(VEGF)\u3068\u764c\u306e\u6d78\u6f64,\u8ee2\u79fb", "subitem_1551255648112": "ja"}, {"subitem_1551255647225": "Vascular endothelial growth factor (VEGF) and tumor invasion/metastasis", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u91d1\u57ce, \u7d00\u4ee3\u5f66", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u82b1\u57ce, \u548c\u5f66", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u6e21\u6176\u6b21, \u8cc0\u535a", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "\u5c0f\u6749, \u5fe0\u8aa0", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "Kinjoh, Kiyohiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hanashiro, Kazuhiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tokeshi, Yoshihiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kosugi, Tadayoshi", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "ja", "subitem_1522651041219": "\u7409\u7403\u533b\u5b66\u4f1a"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "vascular endothelial growth factor (VEGF)"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "vascular permeability factor (VPF)"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "endothehal cell proliferation"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "tumor invasion"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "metastasis"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "The mechanism of invasion and metastasis of malignant tumors have been investigated in many reports especially on the blood coagulation-fibrinolysis system. Recently, on the other hand, it has been clarified that vascular endothelial growth factor (VEGF) plays important roles in tumor invasion and metastasis through the specific action on endothelial cells in tumor tissue. VEGF is known as an angiogenesis factor from tumor tissues, and it is thought to be an important endothelial mitogen for tumor growth; while, a vascular permeability factor (VPF) secreted from tumor tissues has been isolated, whose chemical and biological properties has been studied. Results show that VPF has been identified as VEGF; since VEGF increases vascular permeability and induces endothelial cell proliferation. VEGF also induces the expression of plasminogen activators, plasminogen activator inhibitor-1 or interstitial collagenase in endothelial cells. Platelet derived growth factor has proved to be an inducer of the transcription of VEGF gene by mediating protein kinase C. Hypoxia induces VEGF upregulation and protein expression, that could evoke the angiogenesis on tumor growth. Mutant ras oncogene upregulates VEGF expression. In addition, the expression of VEGF receptor on the endothelial cells in tumor tissues has increased. It has therefore been considered that the inhibitors of VEGF-induced angiogenesis should be useful materials for tumor therapy. Moreover, it has been found that antagonists against the VEGF-receptor, protein kinase C activity and blockers of VEGF-mediated signal transduction should be hopeful means for inhibition of tumor angiogenesis.", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "\u7409\u7403\u533b\u5b66\u4f1a"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "Ryukyu Medical Association"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "jpn"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1346888X"}, {"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0289-1530"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN10369445"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "\u7409\u7403\u533b\u5b66\u4f1a\u8a8c = Ryukyu Medical Journal"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueNumber": "4", "bibliographicPageEnd": "201", "bibliographicPageStart": "193", "bibliographicVolumeNumber": "19"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "v19p193.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2016158/files/v19p193.pdf"}, "version_id": "d107a033-e984-4f19-b727-daa073d0e177"}]}, "item_title": "[\u7dcf\u8aac\uff3d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u6210\u9577\u56e0\u5b50(VEGF)\u3068\u764c\u306e\u6d78\u6f64,\u8ee2\u79fb", "item_type_id": "15", "owner": "1", "path": ["1642838214651", "1642838412624"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002016158", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-07-02"}, "publish_date": "2010-07-02", "publish_status": "0", "recid": "2016158", "relation": {}, "relation_version_is_last": true, "title": ["[\u7dcf\u8aac\uff3d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u6210\u9577\u56e0\u5b50(VEGF)\u3068\u764c\u306e\u6d78\u6f64,\u8ee2\u79fb"], "weko_shared_id": -1}
  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 19巻4号
  1. 部局別インデックス
  2. その他

[総説]血管内皮細胞成長因子(VEGF)と癌の浸潤,転移

http://hdl.handle.net/20.500.12000/0002016158
http://hdl.handle.net/20.500.12000/0002016158
9fc6ee4f-f044-4744-aee0-8882a8bc5e7f
名前 / ファイル ライセンス アクション
v19p193.pdf v19p193.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [総説]血管内皮細胞成長因子(VEGF)と癌の浸潤,転移
言語 ja
作成者 金城, 紀代彦

× 金城, 紀代彦

ja 金城, 紀代彦

花城, 和彦

× 花城, 和彦

ja 花城, 和彦

渡慶次, 賀博

× 渡慶次, 賀博

ja 渡慶次, 賀博

小杉, 忠誠

× 小杉, 忠誠

ja 小杉, 忠誠

Kinjoh, Kiyohiko

× Kinjoh, Kiyohiko

en Kinjoh, Kiyohiko

Hanashiro, Kazuhiko

× Hanashiro, Kazuhiko

en Hanashiro, Kazuhiko

Tokeshi, Yoshihiro

× Tokeshi, Yoshihiro

en Tokeshi, Yoshihiro

Kosugi, Tadayoshi

× Kosugi, Tadayoshi

en Kosugi, Tadayoshi

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 vascular endothelial growth factor (VEGF)
言語 en
主題Scheme Other
主題 vascular permeability factor (VPF)
言語 en
主題Scheme Other
主題 endothehal cell proliferation
言語 en
主題Scheme Other
主題 tumor invasion
言語 en
主題Scheme Other
主題 metastasis
内容記述
内容記述タイプ Other
内容記述 The mechanism of invasion and metastasis of malignant tumors have been investigated in many reports especially on the blood coagulation-fibrinolysis system. Recently, on the other hand, it has been clarified that vascular endothelial growth factor (VEGF) plays important roles in tumor invasion and metastasis through the specific action on endothelial cells in tumor tissue. VEGF is known as an angiogenesis factor from tumor tissues, and it is thought to be an important endothelial mitogen for tumor growth; while, a vascular permeability factor (VPF) secreted from tumor tissues has been isolated, whose chemical and biological properties has been studied. Results show that VPF has been identified as VEGF; since VEGF increases vascular permeability and induces endothelial cell proliferation. VEGF also induces the expression of plasminogen activators, plasminogen activator inhibitor-1 or interstitial collagenase in endothelial cells. Platelet derived growth factor has proved to be an inducer of the transcription of VEGF gene by mediating protein kinase C. Hypoxia induces VEGF upregulation and protein expression, that could evoke the angiogenesis on tumor growth. Mutant ras oncogene upregulates VEGF expression. In addition, the expression of VEGF receptor on the endothelial cells in tumor tissues has increased. It has therefore been considered that the inhibitors of VEGF-induced angiogenesis should be useful materials for tumor therapy. Moreover, it has been found that antagonists against the VEGF-receptor, protein kinase C activity and blockers of VEGF-mediated signal transduction should be hopeful means for inhibition of tumor angiogenesis.
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 19, 号 4, p. 193-201
戻る
0
views
See details
Views

Versions

Ver.1 2022-02-22 04:15:38.509455
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON

確認


Powered by WEKO3


Powered by WEKO3