{"created":"2022-02-22T04:15:36.342993+00:00","id":2016158,"links":{},"metadata":{"_buckets":{"deposit":"3e044463-b846-4564-b404-d8def334e014"},"_deposit":{"id":"2016158","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2016158"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02016158","sets":["1642838163960:1642838198944:1642838199408:1642838214651","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[総説］血管内皮細胞成長因子(VEGF)と癌の浸潤,転移","subitem_1551255648112":"ja"},{"subitem_1551255647225":"Vascular endothelial growth factor (VEGF) and tumor invasion/metastasis","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金城, 紀代彦","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"花城, 和彦","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"渡慶次, 賀博","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"小杉, 忠誠","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"Kinjoh, Kiyohiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hanashiro, Kazuhiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tokeshi, Yoshihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kosugi, Tadayoshi","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"vascular endothelial growth factor (VEGF)"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"vascular permeability factor (VPF)"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"endothehal cell proliferation"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"tumor invasion"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"metastasis"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The mechanism of invasion and metastasis of malignant tumors have been investigated in many reports especially on the blood coagulation-fibrinolysis system. Recently, on the other hand, it has been clarified that vascular endothelial growth factor (VEGF) plays important roles in tumor invasion and metastasis through the specific action on endothelial cells in tumor tissue. VEGF is known as an angiogenesis factor from tumor tissues, and it is thought to be an important endothelial mitogen for tumor growth; while, a vascular permeability factor (VPF) secreted from tumor tissues has been isolated, whose chemical and biological properties has been studied. Results show that VPF has been identified as VEGF; since VEGF increases vascular permeability and induces endothelial cell proliferation. VEGF also induces the expression of plasminogen activators, plasminogen activator inhibitor-1 or interstitial collagenase in endothelial cells. Platelet derived growth factor has proved to be an inducer of the transcription of VEGF gene by mediating protein kinase C. Hypoxia induces VEGF upregulation and protein expression, that could evoke the angiogenesis on tumor growth. Mutant ras oncogene upregulates VEGF expression. In addition, the expression of VEGF receptor on the endothelial cells in tumor tissues has increased. It has therefore been considered that the inhibitors of VEGF-induced angiogenesis should be useful materials for tumor therapy. Moreover, it has been found that antagonists against the VEGF-receptor, protein kinase C activity and blockers of VEGF-mediated signal transduction should be hopeful means for inhibition of tumor angiogenesis.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"jpn"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"201","bibliographicPageStart":"193","bibliographicVolumeNumber":"19"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v19p193.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2016158/files/v19p193.pdf"},"version_id":"d107a033-e984-4f19-b727-daa073d0e177"}]},"item_title":"[総説］血管内皮細胞成長因子(VEGF)と癌の浸潤,転移","item_type_id":"15","owner":"1","path":["1642838214651","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2016158","relation_version_is_last":true,"title":["[総説］血管内皮細胞成長因子(VEGF)と癌の浸潤,転移"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T07:51:31.460443+00:00"}