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[総説]交感神経活動調節におけるRostral Ventrolateral Medulla (RVLM)での Angiotensin Receptor Type 1 (AT_1 receptor)の役割
http://hdl.handle.net/20.500.12000/0002016163
http://hdl.handle.net/20.500.12000/0002016163c0d9b001-f423-4569-a820-67b281852195
名前 / ファイル | ライセンス | アクション |
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Item type | デフォルトアイテムタイプ(フル)(1) | |||||||||
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公開日 | 2010-07-02 | |||||||||
タイトル | ||||||||||
タイトル | [総説]交感神経活動調節におけるRostral Ventrolateral Medulla (RVLM)での Angiotensin Receptor Type 1 (AT_1 receptor)の役割 | |||||||||
言語 | ja | |||||||||
タイトル | ||||||||||
タイトル | The Role of Angiotensin Receptor Type 1 in the Rostral Ventrolateral Medulla in the Regulation of Sympathetic Nerve Activity | |||||||||
言語 | en | |||||||||
作成者 |
田川, 辰也
× 田川, 辰也
× Tagawa, Tatsuya
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アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
権利情報 | ||||||||||
言語 | ja | |||||||||
権利情報 | 琉球医学会 | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Angiotensin | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | sympathetic nerve activity | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | medulla | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | hypothalamus | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | There is a high density of angiotensin type 1 (AT_1) receptors in various brain regions involved in cardiovascular regulation. The present review will focus on the role of AT_1 receptors in regulating the activity of sympathetic premotor neurons in the rostral ventrolateral medulla (RVLM), which plays a pivotal role in the regulation of sympathetic nerve activity and blood pressure. Micoroinjection of angiotensin II into the RVLM results in an increase in renal sympathetic activity and arterial pressure. These effects are blocked by prior injection of AT_1 receptor antagonists. Therefore, angiotensin II activates premotor neurons in the RVLM via AT_1 receptors. Recent evidence indicate that AT_1 receptors play an important role in mediating phasic excitatory inputs to RVLM sympathoexcitatory neurons in response to the activation of some neurons within the hypothalamic paraventricular nucleus (PVN). PVN neurons play an important role in emotional stress and AT_1 receptors may play a significant role in stress-induced hypertension. Further studies are required to determine the mechanisms of action of angiotensin II in the regulation of sympathetic nerve activity under emotional stress condition. | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 論文 | |||||||||
出版者 | ||||||||||
言語 | ja | |||||||||
出版者 | 琉球医学会 | |||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Ryukyu Medical Association | |||||||||
言語 | ||||||||||
言語 | jpn | |||||||||
資源タイプ | ||||||||||
資源タイプ | journal article | |||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
出版タイプ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 1346888X | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 0289-1530 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AN10369445 | |||||||||
収録物名 | ||||||||||
言語 | ja | |||||||||
収録物名 | 琉球医学会誌 = Ryukyu Medical Journal | |||||||||
書誌情報 |
巻 22, 号 3-4, p. 91-94 |