{"created":"2022-02-22T04:15:44.954608+00:00","id":2016163,"links":{},"metadata":{"_buckets":{"deposit":"a9905f17-3a93-4bfc-9e22-6f36087dd3cf"},"_deposit":{"id":"2016163","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2016163"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02016163","sets":["1642838163960:1642838198944:1642838199408:1642838219259","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[総説］交感神経活動調節におけるRostral Ventrolateral Medulla (RVLM)での Angiotensin Receptor Type 1 (AT_1 receptor)の役割","subitem_1551255648112":"ja"},{"subitem_1551255647225":"The Role of Angiotensin Receptor Type 1 in the Rostral Ventrolateral Medulla in the Regulation of Sympathetic Nerve Activity","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田川, 辰也","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"Tagawa, Tatsuya","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Angiotensin"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"sympathetic nerve activity"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"medulla"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"hypothalamus"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"There is a high density of angiotensin type 1 (AT_1) receptors in various brain regions involved in cardiovascular regulation. The present review will focus on the role of AT_1 receptors in regulating the activity of sympathetic premotor neurons in the rostral ventrolateral medulla (RVLM), which plays a pivotal role in the regulation of sympathetic nerve activity and blood pressure. Micoroinjection of angiotensin II into the RVLM results in an increase in renal sympathetic activity and arterial pressure. These effects are blocked by prior injection of AT_1 receptor antagonists. Therefore, angiotensin II activates premotor neurons in the RVLM via AT_1 receptors. Recent evidence indicate that AT_1 receptors play an important role in mediating phasic excitatory inputs to RVLM sympathoexcitatory neurons in response to the activation of some neurons within the hypothalamic paraventricular nucleus (PVN). PVN neurons play an important role in emotional stress and AT_1 receptors may play a significant role in stress-induced hypertension. Further studies are required to determine the mechanisms of action of angiotensin II in the regulation of sympathetic nerve activity under emotional stress condition.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"jpn"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"94","bibliographicPageStart":"91","bibliographicVolumeNumber":"22"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v22p91.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2016163/files/v22p91.pdf"},"version_id":"6846ad25-461f-4e14-bd4a-eeef59467430"}]},"item_title":"[総説］交感神経活動調節におけるRostral Ventrolateral Medulla (RVLM)での Angiotensin Receptor Type 1 (AT_1 receptor)の役割","item_type_id":"15","owner":"1","path":["1642838219259","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2016163","relation_version_is_last":true,"title":["[総説］交感神経活動調節におけるRostral Ventrolateral Medulla (RVLM)での Angiotensin Receptor Type 1 (AT_1 receptor)の役割"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-02-22T04:15:48.150402+00:00"}