{"created":"2022-02-22T04:16:37.945232+00:00","id":2016193,"links":{},"metadata":{"_buckets":{"deposit":"8672505a-4e49-4fb5-bea1-967011c29862"},"_deposit":{"id":"2016193","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2016193"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02016193","sets":["1642838163960:1642838198944:1642838199408:1642838216134","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[総説］尿路結石の基礎と臨床 : シュウ酸と付き合って20年","subitem_1551255648112":"ja"},{"subitem_1551255647225":"Two Decades of Basic Research on Calcium Oxalate Urolithiasis and its Clinical Implications","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小川, 由英","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"Ogawa, Yoshihide","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Oxalate metabolism"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"hyperoxaluria"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"urolithiasis"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"In higher plants, oxalate is synthesized from glycolate (a major product of photorespiration) or ascorbate (a product of photosynthesis), and it regulates calcium activity through the production of an insoluble salt. Under conditions of calcium depletion, however, calcium oxalate crystals can dissolve, presumably providing calcium for plant growth and development. Soluble oxalate and calcium oxalate can inhibit the activity of sucking insects and may also provide a degree of protection against grazing animals. Therefore, oxalates are common constituents of plants and are found in the majority of plant families. Most animals are protected from oxalate toxicity by oxalate-degrading bacteria. In humans, oral intake of oxalate-containing food increases urinary oxalate excretion in three ways, i.e., direct absorption of an oxalate load, endogenous metabolism from vitamin C, and metabolism from glycolate (from glycolate itself and via xylitol or hydroxyproline). The role of the last pathway seems to be underestimated. Mild hyperoxaluria is well known to have an important influence on urinary oxalate saturation and stone formation. There area variety of factors that influence the urinary concentrations of oxalate, calcium, and other stone-related substances. In addition, there is diurnal variation in the urinary saturation of calcium oxalate. Magnesium and citrate salts have been shown to inhibit stone formation in rats, with alkaline salts being more potent. It is hard to predict the level of calcium oxalate saturation using any single parameter. Hypomagnesiuria, a high Ca/Mg ratio, and hypocitraturia were previously believed to be associated with stone formation, but these putative risk factors now seem to be less important. Since a high protein diet has been implicated in stone formation, continuous fluid intake and moderate physical exercise are essential to avoid stone recurrence in stone-formers.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"jpn"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346888X"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0289-1530"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueNumber":"3","bibliographicPageEnd":"115","bibliographicPageStart":"107","bibliographicVolumeNumber":"20"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v20p107.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2016193/files/v20p107.pdf"},"version_id":"646ee1f7-dd99-4f02-a04a-b02bbaa85951"}]},"item_title":"[総説］尿路結石の基礎と臨床 : シュウ酸と付き合って20年","item_type_id":"15","owner":"1","path":["1642838216134","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"2016193","relation_version_is_last":true,"title":["[総説］尿路結石の基礎と臨床 : シュウ酸と付き合って20年"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-02-22T04:16:41.268165+00:00"}