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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 23巻4号
  1. 部局別インデックス
  2. その他

[原著]Airway inflammatory and immunological events in a rat model exposed to toluene diisocyanate

http://hdl.handle.net/20.500.12000/0002016203
http://hdl.handle.net/20.500.12000/0002016203
5f2627ce-adcd-4204-892c-0a3f08ed86f8
名前 / ファイル ライセンス アクション
v23p123.pdf v23p123.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [原著]Airway inflammatory and immunological events in a rat model exposed to toluene diisocyanate
言語 ja
作成者 Kouadio, Kouame

× Kouadio, Kouame

en Kouadio, Kouame

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Zheng, Kui-Cheng

× Zheng, Kui-Cheng

en Zheng, Kui-Cheng

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TuekpeMalletK-N

× TuekpeMalletK-N

en TuekpeMalletK-N

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Ariizumi, Makoto

× Ariizumi, Makoto

en Ariizumi, Makoto

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 toluene dnsocyanate
主題
言語 en
主題Scheme Other
主題 airway hypersensitivity
主題
言語 en
主題Scheme Other
主題 eosinophils
主題
言語 en
主題Scheme Other
主題 cytokines
内容記述
内容記述タイプ Other
内容記述 To investigate the inflammatory and immunological events induced by a short period of repeated exposure to toluene diisocyanate (TDI) in the airway, an animal model, which resembles the industrial field exposure, was established. After Wistar rats were exposed whole bodily to 0.38 and 1.20 ppm 4 h a day for5 consecutive days in a glass chamber, airway symptoms were observed. Bronchoalveolar lavage (BAL) was performed and cellular contents and cytokine productions from BAL fluid were determined. Lung histopathological changes were also examined. The results showed that exposure to both concentrations of TDI vapor resulted in airway hypersensitivity symptoms. BAL fluid cellular analysis revealed that inflammatory response characterized by marked eosinophil infiltration occurred in the airways. Lung histopathological examination showed that TDI-induced bronchitis occurred in the exposed rats. Cytokine assay demonstrated that IL-4 was significantly produced in the airways of the TDI exposed rats. These findings indicated that a short period of exposure to TDI may cause acute respiratory hypersensitivity in which airway inflammation, represented by eosinophil infiltration, and Th2 cytokines may play an important role. This animal model may be a suitable model for exploring the mechanism underlying TDI-induced occupational airway hypersensitivity.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
出版者
言語 en
出版者 Ryukyu Medical Association
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 23, 号 4, p. 123-131
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