@article{oai:u-ryukyu.repo.nii.ac.jp:02016203,
 author = {Kouadio, Kouame and Zheng, Kui-Cheng and TuekpeMalletK-N and Ariizumi, Makoto},
 issue = {4},
 journal = {琉球医学会誌 = Ryukyu Medical Journal},
 note = {To investigate the inflammatory and immunological events induced by a short period of repeated exposure to toluene diisocyanate (TDI) in the airway, an animal model, which resembles the industrial field exposure, was established. After Wistar rats were exposed whole bodily to 0.38 and 1.20 ppm 4 h a day for5 consecutive days in a glass chamber, airway symptoms were observed. Bronchoalveolar lavage (BAL) was performed and cellular contents and cytokine productions from BAL fluid were determined. Lung histopathological changes were also examined. The results showed that exposure to both concentrations of TDI vapor resulted in airway hypersensitivity symptoms. BAL fluid cellular analysis revealed that inflammatory response characterized by marked eosinophil infiltration occurred in the airways. Lung histopathological examination showed that TDI-induced bronchitis occurred in the exposed rats. Cytokine assay demonstrated that IL-4 was significantly produced in the airways of the TDI exposed rats. These findings indicated that a short period of exposure to TDI may cause acute respiratory hypersensitivity in which airway inflammation, represented by eosinophil infiltration, and Th2 cytokines may play an important role. This animal model may be a suitable model for exploring the mechanism underlying TDI-induced occupational airway hypersensitivity., 論文},
 pages = {123--131},
 title = {［原著］Airway inflammatory and immunological events in a rat model exposed to toluene diisocyanate},
 volume = {23}
}