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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球医学会誌
  4. 20巻3号
  1. 部局別インデックス
  2. その他

[総説]I型アレルギーにおけるIgEとその受容体Fc$ \varepsilon $RIの相互反応

http://hdl.handle.net/20.500.12000/0002016208
http://hdl.handle.net/20.500.12000/0002016208
1440181e-1a26-4cdd-8acd-cd2ff0978973
名前 / ファイル ライセンス アクション
v20p117.pdf v20p117.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-07-02
タイトル
タイトル [総説]I型アレルギーにおけるIgEとその受容体Fc$ \varepsilon $RIの相互反応
言語 ja
タイトル
タイトル Interaction between IgE and its receptor (Fc$ \varepsilon $RI) in type-I allergy
言語 en
作成者 花城, 和彦

× 花城, 和彦

ja 花城, 和彦

Search repository
渡慶次, 賀博

× 渡慶次, 賀博

ja 渡慶次, 賀博

Search repository
島田, 誠二

× 島田, 誠二

ja 島田, 誠二

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砂川, 昌範

× 砂川, 昌範

ja 砂川, 昌範

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中村, 真理子

× 中村, 真理子

ja 中村, 真理子

Search repository
小杉, 忠誠

× 小杉, 忠誠

ja 小杉, 忠誠

Search repository
Hanashiro, Kazuhiko

× Hanashiro, Kazuhiko

en Hanashiro, Kazuhiko

Search repository
Tokeshi, Yoshihiro

× Tokeshi, Yoshihiro

en Tokeshi, Yoshihiro

Search repository
Shimada, Seiji

× Shimada, Seiji

en Shimada, Seiji

Search repository
Sunagawa, Masanori

× Sunagawa, Masanori

en Sunagawa, Masanori

Search repository
Nakamura, Mariko

× Nakamura, Mariko

en Nakamura, Mariko

Search repository
Kosugi, Tadayoshi

× Kosugi, Tadayoshi

en Kosugi, Tadayoshi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
主題
言語 en
主題Scheme Other
主題 Type-I allergy
主題
言語 en
主題Scheme Other
主題 IgE-mediated inflammation
主題
言語 en
主題Scheme Other
主題 Fc$ \varepsilon $RI
内容記述
内容記述タイプ Other
内容記述 The type-I allergy is mediated by the interaction between IgE and its high affinity receptor (Fc$ \varepsilon $RI) followed by cross-linking with specific allergen. The binding site for the IgE was identified on the Fc$ \varepsilon $RI $ \alpha $ subunit, and the soluble $ \alpha $ subunit of Fc$ \varepsilon $RI was effective in controlling the lgE-mediated inflammation. Recent studies using IgE knock out mice revealed that IgG could also induce anaphylaxis. However, in the Fc$ \varepsilon $RI $ \alpha $ subunit knock out mice, IgE and IgG could not induce anaphylaxis. These results demonstrated that Fc$ \varepsilon $RI expression is essential for the development of the IgE-mediated inflammation. Further investigation on the interaction between IgE and Fc$ \varepsilon $Rl $ \alpha $ subunit on the membrane of target cells and on signal transduction in the cytoplasma and nucleus should offer novel concepts in developing strategies for the treatment of IgE-mediated inflammation.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球医学会
出版者
言語 en
出版者 Ryukyu Medical Association
言語
言語 jpn
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1346888X
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0289-1530
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 20, 号 3, p. 117-127
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