@article{oai:u-ryukyu.repo.nii.ac.jp:02016229, author = {徳, 誠吉 and Toku, Seikichi}, issue = {1・2}, journal = {琉球医学会誌 = Ryukyu Medical Journal}, note = {Ribosomes are ultramolecules composed of about 80 kinds of ribosomal protein (RP) and 4 kinds of rRNA. Gene expressions of these components are coordinately regulated. Pre-rRNA transcribed in the nucleolus assembles to form pre-ribosomes with RPs imported from cytoplasm. Maturation and processing of the pre-ribosomes are achieved through multiple steps. This article describes our previous works focusing on the followings: i) coupled synthesis between rRNA and RPs, ii) cloning and gene expression of RPs, iii) nucleolar localization signal, iv) a role of RPS19 phosphorylation on pre-ribosomal maturation. The mechanisms for coordination of the synthesis of ribosomal components are also discussed., 論文}, pages = {1--10}, title = {[依頼総説]高等動物におけるリボソーム生合成とその調節}, volume = {29} }