@article{oai:u-ryukyu.repo.nii.ac.jp:02016240,
 author = {Takemoto, Hiroyuki and Kina, Shinichiro and Arakaki, Keiichi and Matayoshi, Akira and Liang, Feixin and Phonaphonh, Thongsavanh and Kuang, Hai and Sunakawa, Hajime and 嵩元, 裕之 and 喜名, 振一郎 and 新垣, 敬一 and 又吉, 亮 and 砂川, 元},
 issue = {3･4},
 journal = {琉球医学会誌 = Ryukyu Medical Journal},
 note = {Angiogenesis induced by inflammation occurs in infected sites and is crucial for the initiation of cancer progression. In cervical cancer, IL-8 (Interleukin-8) production is linked to cancer progression. At inflamed sites, neutrophils deploy a potent antimicrobial arsenal, including ROS. Here, we show that a ROS (H_2O_2) activates p38 MAPK to increase the expression of IL-8 in HeLa cells (HPV18-positive cells). We found that knockdown of HPV (Human Papillomavirus) E6 inhibited H_2O_2- and MG132-induced IL-8 production in HeLa cells. These findings elucidate an interesting signaling pathway by which inflammation can induce angiogenesis to cause cervical cancer progression., 論文},
 pages = {23--30},
 title = {［原著］HPV E6 is an H_2O_2 responsive molecule associated with IL-8 production},
 volume = {29}
}