{"created":"2022-02-22T04:43:59.791307+00:00","id":2016240,"links":{},"metadata":{"_buckets":{"deposit":"2d50ef85-90c9-4951-96f6-9909fb7ed525"},"_deposit":{"id":"2016240","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2016240"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02016240","sets":["1642838163960:1642838198944:1642838199408:1642838227236","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"［原著］HPV E6 is an H_2O_2 responsive molecule associated with IL-8 production","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takemoto, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kina, Shinichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Arakaki, Keiichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matayoshi, Akira","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Liang, Feixin","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Phonaphonh, Thongsavanh","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kuang, Hai","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sunakawa, Hajime","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"嵩元, 裕之","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"喜名, 振一郎","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"新垣, 敬一","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"又吉, 亮","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"砂川, 元","creatorNameLang":"ja"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"琉球医学会","subitem_rights_language":"ja"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"HPV","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"H_2O_2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-8","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Angiogenesis induced by inflammation occurs in infected sites and is crucial for the initiation of cancer progression. In cervical cancer, IL-8 (Interleukin-8) production is linked to cancer progression. At inflamed sites, neutrophils deploy a potent antimicrobial arsenal, including ROS. Here, we show that a ROS (H_2O_2) activates p38 MAPK to increase the expression of IL-8 in HeLa cells (HPV18-positive cells). We found that knockdown of HPV (Human Papillomavirus) E6 inhibited H_2O_2- and MG132-induced IL-8 production in HeLa cells. These findings elucidate an interesting signaling pathway by which inflammation can induce angiogenesis to cause cervical cancer progression.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"琉球医学会","subitem_publisher_language":"ja"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1346-888X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"0289-1530","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN10369445","subitem_source_identifier_type":"NCID"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_source_title":"琉球医学会誌 = Ryukyu Medical Journal","subitem_source_title_language":"ja"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueNumber":"3･4","bibliographicPageEnd":"30","bibliographicPageStart":"23","bibliographicVolumeNumber":"29"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v29(3,4)p23.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2016240/files/v29(3,4)p23.pdf"},"version_id":"cc78a383-675d-456d-9f16-8acad3bdec65"}]},"item_title":"［原著］HPV E6 is an H_2O_2 responsive molecule associated with IL-8 production","item_type_id":"15","owner":"1","path":["1642838227236","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-04-13"},"publish_date":"2012-04-13","publish_status":"0","recid":"2016240","relation_version_is_last":true,"title":["［原著］HPV E6 is an H_2O_2 responsive molecule associated with IL-8 production"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-02-22T04:44:04.881120+00:00"}