@article{oai:u-ryukyu.repo.nii.ac.jp:02016241,
 author = {Matayoshi, Akira and Nakasone, Toshiyuki and Kina, Shinichiro and Arakaki, Keiichi and Takemoto, Hiroyuki and Liang, Feixin and Phonaphonh, Thongsavanh and Kuang, Hai and Sunakawa, Hajime and 又吉, 亮 and 喜名, 振一郎 and 新垣, 敬一 and 嵩元, 裕之 and 砂川, 元},
 issue = {3･4},
 journal = {琉球医学会誌 = Ryukyu Medical Journal},
 note = {Purpose : To predict the risk of delayed cervical lymph node metastasis (delayed-CLN-met) in T1/2 squamous cell carcinoma (SCC) of the tongue, clinicopathological and immunohistochemical characteristics of cervical lymph node metastasis (CLN-met) cases were compared to those negative for cervical lymph node (neg-CLN) involvement. Methods : Clinical characteristics, histopathological parameters, intratumoral lymphatic vessel density (LVD), and intratumoral microvessel density (MVD) were evaluated in 54 patients with T1/2 SCC of the tongue. LVD and MVD were determined by immunohistochemical staining using D2-40 and CD34 antibodies, respectively. Results Parameters significantly correlated with lymph node metastases included T classification (P = 0.0013) and muscle invasion (P = 0.0045). In CLN-met cases, the LVD was significantly higher (P = 0.0003) compared with neg-CLN cases. MVD was not statistically different (P = 0.39) in CLN-met cases compared with neg-CLN cases. Results of multivariate logistic regression analysis for CLN-met showed that T classification and LVD were independent risk factors for CLN-met. Although results of multivariate logistic regression analysis for delayed-CLN-met was not statistically significant, LVD had a tendency to be a risk factor for delayed-CLN-met in univariate analysis (P = 0.05). The depth of SCC invasion into the muscle layer (depth-IM) was statistically significant (P = 0.002). Conclusions : LVD and T classification were independent risk factors for CLN-met; however, in predicting delayed-CLN-met, whether tumor invades to the muscle layer was only a risk factor in T1/2 SCC of the tongue. Although LVD was not statistically significant to predict delayed-CLN-met, LVD had a tendency to be a risk factor for delayed-CLN-met. Cases with depth-IM of > 2 mm and high LVD are thought to be at high risk of delayed-CLN-met in stage 1/2 SCC of the tongue., 論文},
 pages = {31--38},
 title = {［原著］Evaluation of delayed cervical lymph node metastasis in T1/2 squamous cell carcinoma of the tongue},
 volume = {29}
}