@article{oai:u-ryukyu.repo.nii.ac.jp:02016244, author = {小宮, 一郎 and 平良, 伸一郎 and 友寄, 毅昭 and 池間, 朋己 and 益崎, 裕章 and Komiya, Ichiro and Taira, Shin-ichiro and Tomoyose, Takeaki and Ikema, Tomomi and Masuzaki, Hiroaki}, issue = {1-4}, journal = {琉球医学会誌 = Ryukyu Medical Journal}, note = {Low concentrations of high-density lipoprotein cholesterol (HDL-C) or low-density lipoprotein cholesterol (LDL-C) were reported in patients with hematological malignancies and other malignant tumors. Increased cytokines might induce the uptake of LDL-C and HDL-C, and decrease plasma lecithin-cholesterol acyltransferase (LCAT) activity and lipoprotein lipase (LPL) activity, resulting in low serum cholesterol and high serum TG levels. Compared our patients with malignant lymphoma (ML) and adult Tcell leukemia-lymphoma (ATLL) with normal controls, low HDL-C (less than 40 mg/dL) was observed in 60.3% of patients and in 6.2% of controls, and low LDL-C (less than 80mg /dL) was observed in 20.5% of patients and in 9.1% of controls. Lower HDL-C levels were associated with a poorer clinical outcome. Cytokine-induced low HDL-C indicated the disease activity and the prognosis in patients with hematological malignancies, 論文}, pages = {13--19}, title = {[依頼総説]血液悪性疾患と脂質代謝異常 -低 HDL-C 血症合併の検討-}, volume = {30} }