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  1. 学術雑誌論文
  2. 琉球医学会
  3. 琉球大学保健学医学雑誌
  4. 5巻2号
  1. 部局別インデックス
  2. その他

[原著]Specific immunosuppression without genetic restriction in vivo due to spleen extract and diluted antiserum

http://hdl.handle.net/20.500.12000/0002016324
http://hdl.handle.net/20.500.12000/0002016324
05af4b01-77df-4c6a-85e4-79262565f252
名前 / ファイル ライセンス アクション
v5p92.pdf v5p92.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2014-07-18
タイトル
タイトル [原著]Specific immunosuppression without genetic restriction in vivo due to spleen extract and diluted antiserum
言語 ja
作成者 Kinjo, Kiyokatsu

× Kinjo, Kiyokatsu

en Kinjo, Kiyokatsu

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Kosugi, Tadayoshi

× Kosugi, Tadayoshi

en Kosugi, Tadayoshi

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Yamaguchi, Hideyuki

× Yamaguchi, Hideyuki

en Yamaguchi, Hideyuki

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Rokushima, Yoshikazu

× Rokushima, Yoshikazu

en Rokushima, Yoshikazu

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Miyawaki, Keiko

× Miyawaki, Keiko

en Miyawaki, Keiko

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 琉球医学会
内容記述
内容記述タイプ Other
内容記述 The effect of spleen extract and diluted antiserum to antibody production was studied in order to clarify the role of spleen extract in regulation of antibody production. Extracts of normal or pertussis-vaccine-stimulated mouse spleen did not by themselves suppress the primary immune response of mice to sheep or horse red blood cells. Similarly, anti-sheep-red-blood-cell mouse serum did not suppress if administered after 20- to 50-fold dilution. However, when the spleen extract and the diluted antiserum were administered either together with, or a day before the antigen, a very strong suppression of the primary response was observed. Antibody production was not suppressed by a combination of kidney or liver extracts and diluted mouse antisera. The suppressive action observed was specific, and the specificity was determined solely by the specificity of the diluted antiserum used. On the other hand, the stimulatory action of the spleen extract appeared non-specific. Indeed not only mouse spleen extracts but also rat spleen extracts or concentrated bovine spleen extracts exerted a suppressive action on antibody production in mice. The secondary response was suppressed very effectively by the administration of spleen extracts alone. From the above-mentioned results, it was clarified that a specific immunosuppression without genetic restriction was due to spleen extract and diluted antiserum in vivo.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 ja
出版者 琉球大学医学部
出版者
言語 en
出版者 Faculty of Medicine, University of the Ryukyus
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0285-9270
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AN00250763
収録物名
言語 ja
収録物名 琉球大学保健学医学雑誌=Ryukyu University Journal of Health Sciences and Medicine
書誌情報
巻 5, 号 2, p. 92-103
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