@article{oai:u-ryukyu.repo.nii.ac.jp:02016335, author = {野田, 寛 and 栗田, 建一 and 古謝, 将宏 and 新垣, 義孝 and 又吉, 重光 and 源河, 朝博 and 赤松, 隆 and 大城, 修 and Noda, Yutaka and Kurita, Ken-ichi and Koja, Masahiro and Arakaki, Yoshitaka and Matayoshi, Shigemitsu and Genka, Tomohiro and Akamatsu, Takashi and Ohshiro, Osamu}, issue = {3}, journal = {琉球大学保健学医学雑誌=Ryukyu University Journal of Health Sciences and Medicine}, note = {For the purpose of investigating the mechanism of tonsillogenic focal diseases, seventeen kinds of free amino acids (Isoleucine, Leucine , Lysine, Methionine, Phenylalanine, Threonine, Valine, Alanine, Glycine, Proline, Glutamic acid , Serine, Tyrosine, Aspartic acid, Cystine, Histidine and Arginine) were analysed for the tonsils and for the pre- and post-operative plasma in tonsillogenic focal diseases and general inflammatory tonsilar diseases by the column chromatographic method with automatic amino acid analyser (JLC-6AH). The free amino acids were divided into three groups as glucogenic, ketogenic and others according to their metabolic pathways. The results of the present study are summarized as follows. 1) The amounts of free ducogenic, ketogenic and other amino acids were altered unitarily with a same tendency in the tonsils and the pre-operative plasma for individual tonsillogenic focal diseases, and, depleted in the tonsils and the pre-operative plasma for chronic nephritis and accelerated blood sedimentation rate, elevated in the tonsils and the pre-operative plasma for slight fever, elevated in the tonsils and depleted in the pre-operative plasma for rheumatoid arthritis, and elevated in the pre-operative plasma and unchanged in the tonsils for Pustulosis palmaris et plantaris. 2) In relation with the provocation test for tonsils, the amounts of free glucogenic, ketogenic and other amino acids were tend to be depleted in the tonsils and the pre-operative plasma on the positive group, and tend to be elevated in the pre-operative plasma and unchanged in the tonsils on the false positive group. 3) In relation with the tonsillectomy effects for tonsillogenic focal diseases, the amounts of free glucogenic, ketogenic and other amino acids were altered in parallel with their effectiveness in the tonsils and the pre-operative plasma. From the facts that the amounts of free glucogenic, ketogenic and other amino acids were altered with a same tendency in the tonsils and the pre-operative plasma for tonsillogenic focal diseases, it was inferred that these amino acids are concered in the synthesis of proteins, including the production of antibodies or some factor in focal tonsils which cause the secondary focal diseases., 論文}, pages = {232--242}, title = {[原著]扁桃病巣感染症における扁桃組織中ならびに血奬中遊離アミノ酸の代謝経路よりの分析}, volume = {1} }