@article{oai:u-ryukyu.repo.nii.ac.jp:02016440, author = {大浦, 孝 and 佐久本, 政紀 and 三村, 悟郎, 知名, 孝明 and 東, 政弘 and 野原, 雄介 and Oura, Takashi and Sakumoto, Seiki and Mimura, Goro and China, Takaaki and Higashi, Masahiro and Nohara, Usuke}, issue = {2}, journal = {琉球大学保健学医学雑誌=Ryukyu University Journal of Health Sciences and Medicine}, note = {Wereport two cases of nephrotic syndrome during pregnancy. First case is a 28-year-old female and in her third pregnancy. Her first and second pregnancy were nothing in particular. She had been doing well until proteinuria, edema and hypertenision appeared in her 8th month of pregnancy and she was admitted to this hospital. A conservative treatment was prescribed, such as rest, salt restriction and diuretica. However, she complained of dyspnea and oliguria appeared in 33rd week of pregnancy. Cesarean section was performed. She delivered a premature baby, who died after two days. Hypertension and edema improved gradually after delivery, but massive proteinuria continued. She was referred to internal medicine and diagnosed as nephrotic syndrome. Renal biopsy was done one month after delivery, and histopathologically endothelial and mesangial cells proliferation was observed, with findings compatible to pregnancy-kidney. Adrenal corticosteroid treatment was started after the biopsy with very good response. Massive proteinuria improved gradually. Second case is a 21-year-old female in her first pregnancy. She had been doing well until proteinuria, edema and hypertension appeared in her 9th month of pregnancy and she was admitted to this hospital. A conservative treatment was prescribed. In her 38th week of pregnancy the fetal heart sound became irregular but she delivered spontaneously a premature baby that responded favorably. Hypertension and edema improved gradually after the delivery, but massive proteinuria continued. She was referred to internal medicine and diagnosed as nephrotic syndrome. Renal biopsy was done one month after delivery. Histopathological findings was compatible to pregnancy-kidney. Adrenal corticosteroid treatment was started after biopsy, massive proteinuria improved completely. Such cases, nephrotic syndrome during pregnancy are said to be very rare in medical literatures. We reviewed similar cases in medical literatures and introduced that clinical courses and renal histopathological findings. Etiology is presumed to be immunological mechanisms to some antigen produced by the placenta, and that process is promoted by hypercoagulation., 論文}, pages = {170--176}, title = {[原著]ネフローゼ症候群を呈した妊娠腎その病因についての考察}, volume = {2} }