{"created":"2022-02-22T07:17:53.708105+00:00","id":2016874,"links":{},"metadata":{"_buckets":{"deposit":"6cd41d59-192e-4cd9-a455-b3f78d409a63"},"_deposit":{"id":"2016874","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2016874"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02016874","sets":["1642838163960:1642838198944:1642838199408:1642838230007","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"[総説]臨床膵島移植と細胞処理センター","subitem_1551255648112":"ja"},{"subitem_1551255647225":"[Review]Clinical islet transplantation and cell processing center","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野口, 洋文","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"Noguchi, Hirofumi","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"islet transplantation"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"islet isolation"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"cell processing center (CPC)"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"current Good Manufacturing Practice (cGMP)"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Type 1 diabetes mellitus is an autoimmune disease characterized by the destruction of the islets of Langerhans cells, which produce insulin. Pancreatic islet transplantation is a promising option for the treatment of patients with type 1 diabetes who experience hypoglycemic unawareness despite receiving maximal care. Following the successful demonstration of the Edmonton protocol, more than 1,000 patients with type 1 diabetes have been treated at more than 50 institutions using islet transplantation. Clinical islet isolation is currently performed in a Good Manufacturing Practice (cGMP) islet processing facility, called a Cell Processing Center (CPC). The protocol for islet isolation has shown significant advancements on several fronts, including pancreatic ductal protection, improvements in pancreas preservation systems, a new islet purification method and culture/preservation of isolated islets. In this article, we review the current state of research regarding pancreatic islet transplantation.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"jpn"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueNumber":"1･2","bibliographicPageEnd":"12","bibliographicPageStart":"9","bibliographicVolumeNumber":"34"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v34p9.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2016874/files/v34p9.pdf"},"version_id":"e3b4674d-cd16-428e-b215-05c251325830"}]},"item_title":"[総説]臨床膵島移植と細胞処理センター","item_type_id":"15","owner":"1","path":["1642838230007","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-08-01"},"publish_date":"2017-08-01","publish_status":"0","recid":"2016874","relation_version_is_last":true,"title":["[総説]臨床膵島移植と細胞処理センター"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-02-22T07:17:58.896276+00:00"}