@article{oai:u-ryukyu.repo.nii.ac.jp:02016881,
 author = {宮里, 実 and Miyazato, Minoru},
 issue = {1-4},
 journal = {琉球医学会誌 = Ryukyu Medical Journal},
 note = {Painful bladder syndrome/Interstitial cystitis (PBS/IC) is an unknown etiology, characterized by chronic pelvic pain, urinary frequency and urgency. Despite its high incidence, these symptoms in patients with PBS/IC are often very difficult to treat. In this research project, I propose a novel gene therapy using herpes simplex virus (HSV) refractory PBS/IC. By utilizing the natural biology of HSV, HSV-based vectors can deliver gene products to target organ specific sensory pathways, such as the bladder afferents. By changing gene products, numerous inhibitory neurotransmitters, such as gamma-amino butyric acid, opioids and interleukin can be delivered to the bladder afferents, which can inhibit pelvic pain, urinary frequency and urgency. Gene therapy for PBS/IC is a preclinical study in patients with PBS/IC refractory to usual treatment. The log-term objectives of this gene therapy project are to establish a safe and effective method for the treatment of chronic bladder and/or pelvic pain associated with PBS/IC., 論文},
 pages = {1--6},
 title = {膀胱痛・骨盤痛の遺伝子治療},
 volume = {35}
}