@article{oai:u-ryukyu.repo.nii.ac.jp:02016890,
 author = {今村, 美菜子 and Imamura, Minako},
 issue = {1-2},
 journal = {琉球医学会誌 = Ryukyu Medical Journal},
 note = {It has been well known that genetic susceptibility contributes to the risk for type 2 diabetes. Genome-wide association studies (GWAS) have facilitated a substantial and rapid rise in the number of confirmed susceptibility variants for type 2 diabetes. To date, more than 90 type 2 diabetes susceptibility loci have been identified through GWAS. Recently our Japanese study group conducted large-scaled GWAS meta-analysis in the Japanese populations and identified seven novel susceptibility loci for type 2 diabetes. Although the impact of the each GWAS-derived susceptibility locus to the disease risk is modest, accumulation of genetic information in individuals is useful to define a high risk group for the disease in a population. Intensive life style intervention for individuals at genetically high risk may lead efficient prevention of type 2 diabetes in the community. Because the current set of established susceptibility loci accounts for only 10% of genetic susceptibility for type 2 diabetes, more effort to search for the missing heritability would be necessary for translation of genetic information into clinical practice. Functional analysis to uncover the molecular mechanisms for type 2 diabetes susceptibility and integrated studies including genetic factor, environmental factor and interaction between genetic and environmental factors are the future challenges., 論文},
 pages = {9--15},
 title = {個別化医療の実現を目指して : 2型糖尿病疾患感受性遺伝子の解明とその臨床応用},
 volume = {36}
}