{"created":"2022-02-22T07:18:37.174572+00:00","id":2016890,"links":{},"metadata":{"_buckets":{"deposit":"4b083adc-429c-484f-86c1-509fdcc17b6f"},"_deposit":{"id":"2016890","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2016890"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02016890","sets":["1642838163960:1642838198944:1642838199408:1642838231050","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"個別化医療の実現を目指して : 2型糖尿病疾患感受性遺伝子の解明とその臨床応用","subitem_1551255648112":"ja"},{"subitem_1551255647225":"Elucidation of genetic susceptibility for type 2 diabetes and its clinical application","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今村, 美菜子","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"Imamura, Minako","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"琉球医学会"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"type 2 diabetes"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"GWAS"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"genetic susceptibility"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Clinical application"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"It has been well known that genetic susceptibility contributes to the risk for type 2 diabetes. Genome-wide association studies (GWAS) have facilitated a substantial and rapid rise in the number of confirmed susceptibility variants for type 2 diabetes. To date, more than 90 type 2 diabetes susceptibility loci have been identified through GWAS. Recently our Japanese study group conducted large-scaled GWAS meta-analysis in the Japanese populations and identified seven novel susceptibility loci for type 2 diabetes. Although the impact of the each GWAS-derived susceptibility locus to the disease risk is modest, accumulation of genetic information in individuals is useful to define a high risk group for the disease in a population. Intensive life style intervention for individuals at genetically high risk may lead efficient prevention of type 2 diabetes in the community. Because the current set of established susceptibility loci accounts for only 10% of genetic susceptibility for type 2 diabetes, more effort to search for the missing heritability would be necessary for translation of genetic information into clinical practice. Functional analysis to uncover the molecular mechanisms for type 2 diabetes susceptibility and integrated studies including genetic factor, environmental factor and interaction between genetic and environmental factors are the future challenges.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"琉球医学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Ryukyu Medical Association"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"jpn"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1346-888X"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN10369445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"琉球医学会誌 = Ryukyu Medical Journal"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"15","bibliographicPageStart":"9","bibliographicVolumeNumber":"36"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"v36(1-2)p9.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2016890/files/v36(1-2)p9.pdf"},"version_id":"a942ebb5-1d47-4f38-a490-40de336a83b0"}]},"item_title":"個別化医療の実現を目指して : 2型糖尿病疾患感受性遺伝子の解明とその臨床応用","item_type_id":"15","owner":"1","path":["1642838231050","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-12-26"},"publish_date":"2018-12-26","publish_status":"0","recid":"2016890","relation_version_is_last":true,"title":["個別化医療の実現を目指して : 2型糖尿病疾患感受性遺伝子の解明とその臨床応用"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-02-22T07:18:42.582822+00:00"}