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ホルモン感受性前立腺癌における、ホルモン治療開始3か月後のPSA値は全生存期間の予測マーカーである
http://hdl.handle.net/20.500.12000/0002018027
http://hdl.handle.net/20.500.12000/00020180275035fdd5-ac37-43dc-851c-f59e0988b3ce
名前 / ファイル | ライセンス | アクション |
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Item type | 琉球大学リポジトリ登録用アイテムタイプ(1) | |||||||||
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公開日 | 2022-06-09 | |||||||||
タイトル | ||||||||||
タイトル | Three-month early change in prostate-specific antigen levels as a predictive marker for overall survival during hormonal therapy for metastatic hormone-sensitive prostate cancer | |||||||||
言語 | en | |||||||||
タイトル | ||||||||||
タイトル | ホルモン感受性前立腺癌における、ホルモン治療開始3か月後のPSA値は全生存期間の予測マーカーである | |||||||||
言語 | ja | |||||||||
作成者 |
仲西, 昌太郎
× 仲西, 昌太郎
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アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
権利情報 | ||||||||||
言語 | en | |||||||||
権利情報 | © The Author(s) 2021 | |||||||||
権利情報 | ||||||||||
言語 | en | |||||||||
権利情報Resource | http://creativecommons.org/licenses/by/4.0/ | |||||||||
権利情報 | Creative Commons Attribution 4.0 International | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | mHSPC | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Time to CRPC | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Prostate cancer | |||||||||
主題 | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | 3-Month %PSA | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Objective: To date, there are no useful markers for predicting the prognosis of metastatic hormone-sensitive prostate cancer (mHSPC). We evaluated the effect of early changes in prostate-specific antigen (PSA) levels after androgen deprivation therapy (ADT) on castration-resistant prostate cancer (CRPC) progression and overall survival (OS) in mHSPC patients.<br/>Results: In 71 primary mHSPC patients treated with ADT, the median times to CRPC and OS were 15 months and 92 months, respectively. In multivariate analysis, a Gleason score of≥8 (p=0.004), an extent of disease value (EOD) of≥2 (p=0.004), and a 3-month PSA level>1% of the pretreatment level (p=0.017) were independent predictors of shorter time to CRPC. The area under the receiver operating characteristic curve was feasible at 0.822. A 3-month PSA level>1% of the pretreatment level was an independent predictor of OS (p=0.004). Three factors were independent predictors of shorter time to CRPC. A 3-month PSA level>1% of the pretreatment level correlated with a poor prognosis. | |||||||||
言語 | en | |||||||||
出版者 | ||||||||||
言語 | ja | |||||||||
出版者 | 琉球大学 | |||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | University of the Ryukyus | |||||||||
資源タイプ | ||||||||||
資源タイプ | doctoral thesis | |||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
出版タイプ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
関連情報 | ||||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | https://doi.org/10.1186/s13104-021-05641-5 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | EISSN | |||||||||
収録物識別子 | 1756-0500 | |||||||||
収録物名 | ||||||||||
言語 | en | |||||||||
収録物名 | BMC Research Notes | |||||||||
書誌情報 |
巻 14 |
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学位授与番号 | ||||||||||
学位授与番号 | 甲第535号 | |||||||||
学位名 | ||||||||||
学位名 | 博士(医学) | |||||||||
言語 | ja | |||||||||
学位授与年月日 | ||||||||||
学位授与年月日 | 2021-11-18 | |||||||||
学位授与機関 | ||||||||||
学位授与機関識別子 | 18001 | |||||||||
学位授与機関識別子Scheme | kakenhi | |||||||||
学位授与機関名 | 琉球大学 | |||||||||
言語 | ja |