{"_buckets": {"deposit": "8db69357-3ba2-4e7c-8a53-4dd31d261076"}, "_deposit": {"created_by": 8, "id": "2018027", "owner": "8", "owners": [8], "owners_ext": {"displayname": "ryukyu_lib", "username": null}, "pid": {"revision_id": 0, "type": "depid", "value": "2018027"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02018027", "sets": ["1642838159351", "1642838409905"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Three-month early change in prostate-specific antigen levels as a predictive marker for overall survival during hormonal therapy for metastatic hormone-sensitive prostate cancer", "subitem_1551255648112": "en"}, {"subitem_1551255647225": "ホルモン感受性前立腺癌における、ホルモン治療開始3か月後のPSA値は全生存期間の予測マーカーである", "subitem_1551255648112": "ja"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "仲西, 昌太郎", "creatorNameLang": "ja"}, {"creatorName": "Nakanishi, Shotaro", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "en", "subitem_1522651041219": "© The Author(s) 2021"}, {"subitem_1522650717957": "en", "subitem_1522650727486": "http://creativecommons.org/licenses/by/4.0/", "subitem_1522651041219": "Creative Commons Attribution 4.0 International"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "mHSPC"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "Time to CRPC"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "Prostate cancer"}, {"subitem_1522299896455": "en", "subitem_1522300014469": "Other", "subitem_1523261968819": "3-Month %PSA"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Objective: To date, there are no useful markers for predicting the prognosis of metastatic hormone-sensitive prostate cancer (mHSPC). We evaluated the effect of early changes in prostate-specific antigen (PSA) levels after androgen deprivation therapy (ADT) on castration-resistant prostate cancer (CRPC) progression and overall survival (OS) in mHSPC patients.\u003cbr/\u003eResults: In 71 primary mHSPC patients treated with ADT, the median times to CRPC and OS were 15 months and 92 months, respectively. In multivariate analysis, a Gleason score of≥8 (p=0.004), an extent of disease value (EOD) of≥2 (p=0.004), and a 3-month PSA level\u003e1% of the pretreatment level (p=0.017) were independent predictors of shorter time to CRPC. The area under the receiver operating characteristic curve was feasible at 0.822. A 3-month PSA level\u003e1% of the pretreatment level was an independent predictor of OS (p=0.004). Three factors were independent predictors of shorter time to CRPC. A 3-month PSA level\u003e1% of the pretreatment level correlated with a poor prognosis.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "琉球大学"}, {"subitem_1522300295150": "en", "subitem_1522300316516": "University of the Ryukyus"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "EISSN", "subitem_1522646572813": "1756-0500"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "BMC Research Notes"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicVolumeNumber": "14"}]}, "item_1617187087799": {"attribute_name": "Dissertation Number", "attribute_value_mlt": [{"subitem_1551256171004": "甲第535号"}]}, "item_1617187112279": {"attribute_name": "Degree Name", "attribute_value_mlt": [{"subitem_1551256126428": "博士(医学)", "subitem_1551256129013": "ja"}]}, "item_1617187136212": {"attribute_name": "Date Granted", "attribute_value_mlt": [{"subitem_1551256096004": "2021-11-18"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1186/s13104-021-05641-5"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2022-06-09"}], "download_preview_message": "", "file_order": 0, "filename": "iken535abstract.pdf", "filesize": [{"value": "1016 KB"}], "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 1016000.0, "url": {"objectType": "abstract", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2018027/files/iken535abstract.pdf"}, "version_id": "aadd0cf1-04a7-4845-87f1-21e5eb3ea027"}, {"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2022-06-09"}], "download_preview_message": "", "file_order": 1, "filename": "iken535review.pdf", "filesize": [{"value": "884 KB"}], "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 884000.0, "url": {"objectType": "other", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2018027/files/iken535review.pdf"}, "version_id": "85545f45-b2cc-4519-8498-0609d1870daa"}, {"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2022-06-09"}], "download_preview_message": "", "file_order": 2, "filename": "iken535text.pdf", "filesize": [{"value": "755 KB"}], "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 755000.0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2018027/files/iken535text.pdf"}, "version_id": "9c8960ca-0067-46fc-b1c0-35da8b83c895"}]}, "item_1617944105607": {"attribute_name": "Degree Grantor", "attribute_value_mlt": [{"subitem_1551256015892": [{"subitem_1551256027296": "18001", "subitem_1551256029891": "kakenhi"}], "subitem_1551256037922": [{"subitem_1551256042287": "琉球大学", "subitem_1551256047619": "ja"}]}]}, "item_title": "Three-month early change in prostate-specific antigen levels as a predictive marker for overall survival during hormonal therapy for metastatic hormone-sensitive prostate cancer", "item_type_id": "59", "owner": "8", "path": ["1642838159351", "1642838409905"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002018027", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-06-09"}, "publish_date": "2022-06-09", "publish_status": "0", "recid": "2018027", "relation": {}, "relation_version_is_last": true, "title": ["Three-month early change in prostate-specific antigen levels as a predictive marker for overall survival during hormonal therapy for metastatic hormone-sensitive prostate cancer"], "weko_shared_id": -1}