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  1. 学位論文
  2. 博士論文
  3. 医学研究科
  1. 部局別インデックス
  2. 医学研究科

ホルモン感受性前立腺癌における、ホルモン治療開始3か月後のPSA値は全生存期間の予測マーカーである

http://hdl.handle.net/20.500.12000/0002018027
http://hdl.handle.net/20.500.12000/0002018027
5035fdd5-ac37-43dc-851c-f59e0988b3ce
名前 / ファイル ライセンス アクション
iken535abstract.pdf iken535abstract.pdf (1016 KB)
iken535review.pdf iken535review.pdf (884 KB)
iken535text.pdf iken535text.pdf (755 KB)
Item type 琉球大学リポジトリ登録用アイテムタイプ(1)
公開日 2022-06-09
タイトル
タイトル Three-month early change in prostate-specific antigen levels as a predictive marker for overall survival during hormonal therapy for metastatic hormone-sensitive prostate cancer
言語 en
タイトル
タイトル ホルモン感受性前立腺癌における、ホルモン治療開始3か月後のPSA値は全生存期間の予測マーカーである
言語 ja
作成者 仲西, 昌太郎

× 仲西, 昌太郎

ja 仲西, 昌太郎

en Nakanishi, Shotaro

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 © The Author(s) 2021
権利情報
言語 en
権利情報Resource http://creativecommons.org/licenses/by/4.0/
権利情報 Creative Commons Attribution 4.0 International
主題
言語 en
主題Scheme Other
主題 mHSPC
主題
言語 en
主題Scheme Other
主題 Time to CRPC
主題
言語 en
主題Scheme Other
主題 Prostate cancer
主題
言語 en
主題Scheme Other
主題 3-Month %PSA
内容記述
内容記述タイプ Abstract
内容記述 Objective: To date, there are no useful markers for predicting the prognosis of metastatic hormone-sensitive prostate cancer (mHSPC). We evaluated the effect of early changes in prostate-specific antigen (PSA) levels after androgen deprivation therapy (ADT) on castration-resistant prostate cancer (CRPC) progression and overall survival (OS) in mHSPC patients.<br/>Results: In 71 primary mHSPC patients treated with ADT, the median times to CRPC and OS were 15 months and 92 months, respectively. In multivariate analysis, a Gleason score of≥8 (p=0.004), an extent of disease value (EOD) of≥2 (p=0.004), and a 3-month PSA level>1% of the pretreatment level (p=0.017) were independent predictors of shorter time to CRPC. The area under the receiver operating characteristic curve was feasible at 0.822. A 3-month PSA level>1% of the pretreatment level was an independent predictor of OS (p=0.004). Three factors were independent predictors of shorter time to CRPC. A 3-month PSA level>1% of the pretreatment level correlated with a poor prognosis.
言語 en
出版者
言語 ja
出版者 琉球大学
出版者
言語 en
出版者 University of the Ryukyus
資源タイプ
資源タイプ doctoral thesis
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s13104-021-05641-5
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 1756-0500
収録物名
言語 en
収録物名 BMC Research Notes
書誌情報
巻 14
学位授与番号
学位授与番号 甲第535号
学位名
学位名 博士(医学)
言語 ja
学位授与年月日
学位授与年月日 2021-11-18
学位授与機関
学位授与機関識別子 18001
学位授与機関識別子Scheme kakenhi
学位授与機関名 琉球大学
言語 ja
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