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アイテム
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ホルモン感受性前立腺癌における、ホルモン治療開始3か月後のPSA値は全生存期間の予測マーカーである
http://hdl.handle.net/20.500.12000/0002018027
http://hdl.handle.net/20.500.12000/00020180275035fdd5-ac37-43dc-851c-f59e0988b3ce
| 名前 / ファイル | ライセンス | アクション | |
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iken535abstract.pdf (1016 KB)
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iken535review.pdf (884 KB)
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iken535text.pdf (755 KB)
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| Item type | 琉球大学リポジトリ登録用アイテムタイプ(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2022-06-09 | |||||||||
| タイトル | ||||||||||
| タイトル | ホルモン感受性前立腺癌における、ホルモン治療開始3か月後のPSA値は全生存期間の予測マーカーである | |||||||||
| 言語 | ja | |||||||||
| 作成者 |
仲西, 昌太郎
× 仲西, 昌太郎
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 言語 | en | |||||||||
| 権利情報 | © The Author(s) 2021 | |||||||||
| 言語 | en | |||||||||
| 権利情報Resource | http://creativecommons.org/licenses/by/4.0/ | |||||||||
| 権利情報 | Creative Commons Attribution 4.0 International | |||||||||
| 主題 | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | mHSPC | |||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Time to CRPC | |||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Prostate cancer | |||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 3-Month %PSA | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Objective: To date, there are no useful markers for predicting the prognosis of metastatic hormone-sensitive prostate cancer (mHSPC). We evaluated the effect of early changes in prostate-specific antigen (PSA) levels after androgen deprivation therapy (ADT) on castration-resistant prostate cancer (CRPC) progression and overall survival (OS) in mHSPC patients.<br/>Results: In 71 primary mHSPC patients treated with ADT, the median times to CRPC and OS were 15 months and 92 months, respectively. In multivariate analysis, a Gleason score of≥8 (p=0.004), an extent of disease value (EOD) of≥2 (p=0.004), and a 3-month PSA level>1% of the pretreatment level (p=0.017) were independent predictors of shorter time to CRPC. The area under the receiver operating characteristic curve was feasible at 0.822. A 3-month PSA level>1% of the pretreatment level was an independent predictor of OS (p=0.004). Three factors were independent predictors of shorter time to CRPC. A 3-month PSA level>1% of the pretreatment level correlated with a poor prognosis. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 言語 | ja | |||||||||
| 出版者 | 琉球大学 | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | doctoral thesis | |||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連情報 | ||||||||||
| 関連識別子 | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1186/s13104-021-05641-5 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 1756-0500 | |||||||||
| 収録物名 | ||||||||||
| 言語 | en | |||||||||
| 収録物名 | BMC Research Notes | |||||||||
| 書誌情報 |
巻 14 |
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| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第535号 | |||||||||
| 学位名 | ||||||||||
| 学位名 | 博士(医学) | |||||||||
| 言語 | ja | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2021-11-18 | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子 | ||||||||||
| 学位授与機関識別子 | 18001 | |||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関名 | ||||||||||
| 学位授与機関名 | 琉球大学 | |||||||||
| 言語 | ja | |||||||||
