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  1. 学位論文
  2. 博士論文
  3. 医学研究科
  1. 部局別インデックス
  2. 医学研究科

精神病状態を呈した20歳未満の外来初診患者の精神病理と臨床転帰

http://hdl.handle.net/20.500.12000/0002018037
http://hdl.handle.net/20.500.12000/0002018037
9a9456e0-cca9-4e4a-b475-3cf69c8f26fc
名前 / ファイル ライセンス アクション
iken542abstract.pdf iken542abstract.pdf (1.3 MB)
iken542review.pdf iken542review.pdf (995 KB)
iken542text.pdf iken542text.pdf (178 KB)
Item type 琉球大学リポジトリ登録用アイテムタイプ(1)
公開日 2022-06-13
タイトル
タイトル 精神病状態を呈した20歳未満の外来初診患者の精神病理と臨床転帰
言語 ja
作成者 石橋, 孝勇

× 石橋, 孝勇

ja 石橋, 孝勇

en Ishibashi, Takao

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
言語 en
主題Scheme Other
主題 under 20
言語 en
主題Scheme Other
主題 schizophrenia
言語 en
主題Scheme Other
主題 at risk mental state
言語 en
主題Scheme Other
主題 early symptoms
言語 en
主題Scheme Other
主題 insight
内容記述
内容記述タイプ Abstract
内容記述 Aim: This study aimed to clarify the psychopathology, global functioning and clinical outcome of patients under 20 years old exhibiting a psychotic state. Methods: Forty-five patients (15 males and 30 females) under 20 years old with a diagnostic description of psychosis, schizophrenia, at-risk mental state (ARMS) or psychotic-like experiences, who had first visited our clinic between January 2012 and December 2017 were retrospectively extracted from medical records. Their age at the onset of symptoms; psychiatric diagnoses, including comorbidities; insight of disease; symptomatology (early, positive, negative, catatonic and anxiety-depression symptoms); course of illness; prescribed medication; and final treatment outcome were investigated from various aspects. Results: Prodromal stages of schizophrenia (ARMS and early schizophrenia) were observed in about one-third of the overall patients. Patients with insight of disease had a higher baseline global assessment of functioning and greater number of early schizophrenic symptoms and anxiety-depression symptoms than those without insight of disease. In particular, early schizophrenic symptoms appear to be a discriminating factor for insight of disease. A total of 36.4% of ARMS patients converted to schizophrenia, while 25% of early schizophrenia patients converted to frank schizophrenia. Doses of antipsychotics (chlorpromazine equivalence: mg/day) were lower in ARMS non-converters (100 ± 63) than in ARMS converters (364 ± 44) or schizophrenics (477 ± 337). Among overall patients, 62.3% showed improvement as the final treatment outcome. The global assessment of functioning values were higher at 6 (54.2% ± 17.2%) and 12 months (55.1% ± 18.9%) than that at baseline (34.1% ± 10.3%).
Conclusion: The present study suggests that clinicians need to actively ask about early symptoms or attenuated positive symptoms in patients under 20 years old with a psychotic state who may still have insight of disease and encourage voluntary help-seeking. The first six months might be a critical period for achieving symptomatological remission and functional recovery in these patients.
言語 en
出版者
言語 ja
出版者 琉球大学
言語
言語 eng
資源タイプ
資源タイプ doctoral thesis
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
関連識別子
識別子タイプ HDL
関連識別子 http://hdl.handle.net/20.500.12000/0002018035
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 1346-888X
収録物識別子タイプ NCID
収録物識別子 AN10369445
収録物名
言語 ja
収録物名 琉球医学会誌 = Ryukyu Medical Journal
書誌情報
巻 39, 号 1-4, p. 29-40
学位授与番号
学位授与番号 甲第542号
学位名
学位名 博士(医学)
言語 ja
学位授与年月日
学位授与年月日 2022-03-18
学位授与機関
学位授与機関識別子
学位授与機関識別子 18001
学位授与機関識別子Scheme kakenhi
学位授与機関名
学位授与機関名 琉球大学
言語 ja
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