@phdthesis{oai:u-ryukyu.repo.nii.ac.jp:02019519,
 author = {西山, 直哉},
 note = {infants, elderly adults, and immunosuppressed patients. Generally, GBS is susceptible to penicillin; however, GBS withreduced penicillin susceptibility (PRGBS) has been reported. PRGBS are commonly isolated from respiratory specimens,but clinical features of patients with PRGBS remain unclear. In this case–control study, clinical features of patients withPRGBS and bacterial characteristics of these isolates from respiratory specimens were investigated. Patients with GBS atthe University of the Ryukyus Hospital between January 2017 and June 2018 were retrospectively investigated. GBS werefurther classified into penicillin-susceptible GBS (PSGBS) and PRGBS using a drug susceptibility test. Moreover, serotypes,genotypes, and drug resistance genes of PRGBS isolates were determined. In total, 362 GBS were isolated, of which 46 werecollected from respiratory specimens, which had the highest rate of PRGBS (24%). Compared to patients with PSGBS, thosewith PRGBS were more likely to have neuromuscular disease, poor performance status, risk of multidrug-resistant pathogeninfection, prior pneumonia history within 1 year, and prior penicillin use within 1 year. Among eight PRGBS isolates, multilocussequence typing revealed that five isolates were sequence type (ST) 358, two were ST3 and ST10, respectively, and oneisolate was ST1404. All PRGBS isolates belonged to the ST1/ST19/ST10 group. This study reveals clinical characteristicsof patients with PRGBS from respiratory specimens. Because invasive GBS infection cases are increasing, especially in theelderly, more attention should be paid to this infection.},
 school = {琉球大学},
 title = {Clinical and bacterial features of Group B streptococci with reduced penicillin susceptibility  from respiratory specimens: a case-control study}
}