{"created":"2022-10-06T06:24:53.692454+00:00","id":2019520,"links":{},"metadata":{"_buckets":{"deposit":"97377eb8-3c25-4863-b35c-2e94ecd2d11c"},"_deposit":{"created_by":14,"id":"2019520","owner":"14","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"2019520"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02019520","sets":["1642838158423:1642838158860:1642838159351","1642838403551:1642838409905"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Association of Urinary Angiotensinogen with Renal Arteriolar Remodeling in Chronic Kidney Disease","subitem_title_language":"en"},{"subitem_title":"慢性腎臓病における尿中アンジオテンシノーゲンと腎細動脈リモデリングとの関連","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金光, 崇史","creatorNameLang":"ja"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2022 Wolters Kluwer Health, Inc. All rights reserved.","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"arteriolar remodeling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic kidney diseas","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"renal renin-angiotensin system","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Objective: Renin-angiotensin system (RAS) might be associated with arteriolar remodeling. The present study aimed to explore the hitherto unknown relationship between renal RAS and renal arteriolar remodeling and to elucidate whether altered renal RAS subsequently affects renal function in patients with chronic kidney disease (CKD).\nMethods: In this retrospective study, patients with various CKDs not using RAS inhibitors who underwent renal biopsy were included in cross-sectional and longitudinal analyses. Urinary angiotensinogen (UAGT) levels and wall/lumen ratio (WLR) were determined to evaluate renal RAS and renal arteriolar remodeling, respectively. The association between ln(UAGT) and ln(WLR) was cross-sectionally examined using a liner regression model. Furthermore, the association of ln(UAGT) with subsequent changes in estimated glomerular filtration rate (eGFR) per year were longitudinally examined in the largest subgroup of patients who were diagnosed with IgA nephropathy.\nResults: In the overall cohort (n = 54), the median age, blood pressures, eGFR, and WLR were 37 years, 120/73 mmHg, 85 ml/min per 1.73 m2, and 0.93, respectively. Ln(UAGT) was significantly and positively associated with ln(WLR) even after adjusting for classical and nonclassical clinical renal risk factors. In patients with IgA nephropathy, higher ln(UAGT) was associated with higher ln(WLR). Ln(UAGT) also tended to be associated with a greater decline in eGFR per year over a median period of 8.7 years, even after adjusting for potential confounding factors.\nConclusion: In patients with CKD, renal RAS might be associated with renal arteriolar remodeling and future decline in eGFR, independent of potential risk factors.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"琉球大学","subitem_publisher_language":"ja"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617187087799":{"attribute_name":"Dissertation Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第544号"}]},"item_1617187112279":{"attribute_name":"Degree Name","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_1617187136212":{"attribute_name":"Date Granted","attribute_value_mlt":[{"subitem_dategranted":"2022-03-18"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-10-06"}],"filename":"iken544abstract.pdf","filesize":[{"value":"996 KB"}],"url":{"objectType":"abstract","url":"https://u-ryukyu.repo.nii.ac.jp/record/2019520/files/iken544abstract.pdf"},"version_id":"b56d771d-ea2d-4b4d-9a85-e221592cd6f9"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2022-10-06"}],"filename":"iken544review.pdf","filesize":[{"value":"819 KB"}],"url":{"objectType":"other","url":"https://u-ryukyu.repo.nii.ac.jp/record/2019520/files/iken544review.pdf"},"version_id":"a53b2348-943f-44db-9a49-7494c227cdfe"}]},"item_1617944105607":{"attribute_name":"Degree Grantor","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"琉球大学"}],"subitem_degreegrantor_identifie":[{"subitem_degreegrantor_identifier_name":"18001","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_title":"Association of Urinary Angiotensinogen with Renal Arteriolar Remodeling in Chronic Kidney Disease","item_type_id":"59","owner":"14","path":["1642838159351","1642838409905"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-08-31"},"publish_date":"2022-08-31","publish_status":"0","recid":"2019520","relation_version_is_last":true,"title":["Association of Urinary Angiotensinogen with Renal Arteriolar Remodeling in Chronic Kidney Disease"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2022-10-06T06:31:07.670009+00:00"}