@article{oai:u-ryukyu.repo.nii.ac.jp:02019575, author = {平良, 勝己 and Taira, Katsumi and 中山, 正彦 and Nakayama, Masahiko and 比嘉, 昇 and Higa, Noboru and 玉木, 正人 and Tamaki, Masato and 上里, 忠興 and Uezato, Tadaoki}, issue = {1-4}, journal = {琉球医学会誌 = Ryukyu Medical Journal}, month = {Oct}, note = {The patient was a 47-year-old woman, who was receiving oral medication for schizophrenia and hyperthyroidism. She was diagnosed as generalized peritonitis associated with idiopathic rectal perforation and underwent the Hartmannʼs procedure. She exhibited a fever of 40℃, muscle rigidity, hypomimia, profuse sweating, and tachycardia of 130 beats / min from the 8th day of illness. Exacerbation of peritonitis was suspected, and antibiotics were administered, but no improvements were observed. Neuroleptic malignant syndrome was suspected due to a rise in creatine phosphokinase(CPK)and the suspension of orally administered antipsychotics. Upon administration of dantrolene sodium from the 10th day of illness, the patientʼs fever decreased to 36℃, and she showed improvement in general condition by the 16th day of illness. It was difficult to distinguish between residual abscesses after generalized peritonitis and neuroleptic malignant syndrome as the cause of persistent fever. However, we report on this case, with some literature review, since the patient experienced malignant syndrome, which developed after idiopathic rectal perforation, that was treated by the use of dantrolene sodium.}, pages = {47--53}, title = {特発性直腸穿孔術後に発症した悪性症候群の 1 例}, volume = {40}, year = {2021} }