{"created":"2023-01-27T01:16:37.738006+00:00","id":2019613,"links":{},"metadata":{"_buckets":{"deposit":"9b3e70e6-6d38-44c9-a53b-ef18f28d38ab"},"_deposit":{"created_by":8,"id":"2019613","owner":"8","owners":[8],"owners_ext":{"displayname":"ryukyu_lib","username":null},"pid":{"revision_id":0,"type":"depid","value":"2019613"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02019613","sets":["1642838163960:1642838338003","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Changes in Pharmacodynamic Parameters during Co-administration of 5-FU with Warfarin: A Retrospective Case Series","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tayag, Jose Carlos S.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishii, Takeo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kokuba, Shun","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirata, Tetsuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shiohira, Hideo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamura, Katsunori","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"en","subitem_1522651041219":"© 2022 The Pharmaceutical Society of Japan"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"5-fluorouracil"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"warfarin"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"fluoropyrimidine"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"CYP"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"drug interaction"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"chemotherapy"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Drug–drug interactions (DDIs) between warfarin (WF) and fluoropyrimidines are well known. Co-administration of WF and 5-fluorouracil (5-FU) leads to elevations in prothrombin time international normalised ratio (PT-INR). The inhibition of drug metabolism through suppression of CYP activity is a possible cause of prolonged PT-INR elevations. 5-FU and its metabolites are suspected to inhibit CYPs, but the precise mechanisms of action remain unknown. This study aimed to investigate the possible DDI effects of the co-administration of 5-FU with WF using PT-INR and PT-INR/dose ratio as pharmacodynamic parameters. Retrospective case series data were collected from patients who received parenteral 5-FU chemotherapy from April 2009 to December 2019 at the University of the Ryukyus Hospital. Seven patients who received 5-FU in combination with WF were analysed. There was a significant increase in PT-INR and PT-INR/dose during the co-administration of WF and 5-FU (p= 0.0018 and p= 0.0187, respectively; paired t-test). The findings demonstrated significant DDI between 5-FU and WF evident as elevated PT-INR and PT-INR/dose ratio.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"The Pharmaceutical Society of Japan"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"EISSN","subitem_1522646572813":"1347-5215"},{"subitem_1522646500366":"PISSN","subitem_1522646572813":"0918-6158"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"Biological and Pharmaceutical Bulletin"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1105","bibliographicPageStart":"1101","bibliographicVolumeNumber":"45"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1248/bpb.b22-00129"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-01-27"}],"filename":"45_b22-00129.pdf","filesize":[{"value":"483 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2019613/files/45_b22-00129.pdf"},"version_id":"8ba7baed-c861-438e-8801-7e4b63fac468"}]},"item_title":"Changes in Pharmacodynamic Parameters during Co-administration of 5-FU with Warfarin: A Retrospective Case Series","item_type_id":"59","owner":"8","path":["1642838338003","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-01-27"},"publish_date":"2023-01-27","publish_status":"0","recid":"2019613","relation_version_is_last":true,"title":["Changes in Pharmacodynamic Parameters during Co-administration of 5-FU with Warfarin: A Retrospective Case Series"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2023-08-03T05:37:58.065232+00:00"}