{"_buckets": {"deposit": "c8421e4f-4ac5-4ae4-8de5-24172b2212b8"}, "_deposit": {"created_by": 8, "id": "2019653", "owner": "8", "owners": [8], "owners_ext": {"displayname": "ryukyu_lib", "username": null}, "pid": {"revision_id": 0, "type": "depid", "value": "2019653"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02019653", "sets": ["1642838407795", "1642838338003"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Survivin: A novel marker and potential therapeutic target for human angiosarcoma", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tsuneki, Masayuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kinjo, Takao", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mori, Taisuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yoshida, Akihiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kuyama, Kayo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohira, Aoi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Miyagi, Takuya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takahashi, Kenzo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kawai, Akira", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Chuman, Hirokazu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamazaki, Naoya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Masuzawa, Mikio", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Arakawa, Hirofumi", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "en", "subitem_1522651041219": "© 2017 The Authors"}, {"subitem_1522650717957": "en", "subitem_1522650727486": "https://creativecommons.org/licenses/by-nc/4.0/", "subitem_1522651041219": "This is an open access article under the terms of the Creative Commons Attrib ution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Human angiosarcoma is a rare malignant vascular tumor associated with extremely poor clinical outcome and generally arising in skin of the head and neck region. However, little is known about the molecular pathogeneses and useful immunohistochemical markers of angiosarcoma. To investigate the mechanisms of angiosarcoma progression, we collected 85 cases of human angiosarcoma specimens with clinical records and analyzed ISO-HAS-B patient-derived angiosarcoma cells. As control subjects, 54 cases of hemangioma and 34 of pyogenic granuloma were collected. Remarkably, consistent with our recent observations regarding the involvement of survivin expression following Hippo pathway inactivation in the neoplastic proliferation of murine hemangioendothelioma cells and human infantile hemangioma, nuclear survivin expression was observed in all cases of angiosarcoma but not in hemangiomas and pyogenic granulomas, and the Hippo pathway was inactivated in 90.3% of yes-associated protein (YAP)-positive angiosarcoma cases. However, survivin expression modes and YAP localization (Hippo pathway activation modes) were not correlated with survival. In addition, we confirmed that survivin small interference RNA (siRNA) transfection and YM155, an anti-survivin drug, elicited decreased nuclear survivin expression and cell proliferation in ISO-HAS-B cells which expressed survivin consistently. Conclusively, these findings support the importance of survivin as a good marker and critical regulator of cellular proliferation for human angiosarcoma and YM155 as a potential therapeutic agent.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "en", "subitem_1522300316516": "Wiley Open Access"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "PISSN", "subitem_1522646572813": "1347-9032"}, {"subitem_1522646500366": "EISSN", "subitem_1522646572813": "1349-7006"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "Cancer Science"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "2305", "bibliographicPageStart": "2295", "bibliographicVolumeNumber": "108"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1111/cas.13379"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2023-03-23"}], "download_preview_message": "", "file_order": 0, "filename": "CAS-108-2295.pdf", "filesize": [{"value": "3 MB"}], "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 3000000.0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2019653/files/CAS-108-2295.pdf"}, "version_id": "a850144e-97b3-44cf-a412-e63cb9b36d3c"}]}, "item_title": "Survivin: A novel marker and potential therapeutic target for human angiosarcoma", "item_type_id": "59", "owner": "8", "path": ["1642838338003", "1642838407795"], "permalink_uri": "http://hdl.handle.net/20.500.12000/0002019653", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2023-03-23"}, "publish_date": "2023-03-23", "publish_status": "0", "recid": "2019653", "relation": {}, "relation_version_is_last": true, "title": ["Survivin: A novel marker and potential therapeutic target for human angiosarcoma"], "weko_shared_id": -1}