@article{oai:u-ryukyu.repo.nii.ac.jp:02019953,
 author = {Miyagi, Takuya and Kanai, Yasumasa and Murotani, Kenta and Okubo, Yukari and Honma, Masaru and Kobayashi, Satomi and Seishima, Mariko and Mizutani, Yoko and Kitabayashi, Hiroki and Imafuku, Shinichi},
 journal = {JAAD International},
 month = {Sep},
 note = {Background: Patients with psoriasis report impaired health-related quality of life (HRQoL; Dermatology Life Quality Index score $ 2) even after achieving clear or almost-clear skin with biologic treatment.
Objective: To assess the effectiveness of brodalumab in HRQoL improvement and the factors associated with incomplete HRQoL improvement in Japanese patients with psoriasis.
Methods: As a part of the single-arm, open-label, multicenter, prospective ProLOGUE study (Japan Registry of Clinical Trials identifier: jRCTs031180037), patients were treated with 210 mg of subcutaneous brodalumab in daily clinical practice until week 48. The absolute Psoriasis Area and Severity Index scores and patient-reported outcomes were assessed at baseline and weeks 12 and 48.
Results: Seventy-three patients (male, 82.2%; median age, 54.0 years) were enrolled. The Dermatology Life Quality Index and European Quality of Life 5-Dimension 5-Level Utility Index scores significantly improved from baseline to weeks 12 and 48. At week 48, all 13 patients with a Dermatology Life Quality Index score of $2 and an absolute Psoriasis Area and Severity Index score of 0 to #2 reported itching.
Limitations: Unclear generalizability of the results to other biologics.
Conclusion: Treatment with brodalumab improved HRQoL in patients with psoriasis. Itching may contribute to incomplete HRQoL improvement in patients who have achieved clear or almost-clear skin. ( JAAD Int 2022;8:146-53.)},
 pages = {146--153},
 title = {Itch as a critical factor in impaired health-related quality of life in patients with plaque psoriasis achieving clear or almost-clear skin: Analysis of the singlearm, open-label, multicenter, prospective ProLOGUE study},
 volume = {8},
 year = {2022}
}