{"created":"2023-07-25T06:51:48.760874+00:00","id":2019953,"links":{},"metadata":{"_buckets":{"deposit":"3495c336-5cb3-4214-8c49-b5b3a72e31c3"},"_deposit":{"created_by":8,"id":"2019953","owner":"8","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2019953"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02019953","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"control_number":"2019953","item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Itch as a critical factor in impaired health-related quality of life in patients with plaque psoriasis achieving clear or almost-clear skin: Analysis of the singlearm, open-label, multicenter, prospective ProLOGUE study","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyagi, Takuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kanai, Yasumasa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Murotani, Kenta","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okubo, Yukari","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Honma, Masaru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kobayashi, Satomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Seishima, Mariko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mizutani, Yoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kitabayashi, Hiroki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Imafuku, Shinichi","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"en","subitem_1522651041219":"© 2022 by the American Academy of Dermatology, Inc. Published by Elsevier Inc."},{"subitem_1522650717957":"en","subitem_1522650727486":"https://creativecommons.org/licenses/by/4.0/","subitem_1522651041219":"This is an open access article under the CC BY license"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"absolute PASI"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"brodalumab"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"health-related quality of life"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"itching"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"plaque psoriasis"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"real-life patients"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Background: Patients with psoriasis report impaired health-related quality of life (HRQoL; Dermatology Life Quality Index score $ 2) even after achieving clear or almost-clear skin with biologic treatment.\nObjective: To assess the effectiveness of brodalumab in HRQoL improvement and the factors associated with incomplete HRQoL improvement in Japanese patients with psoriasis.\nMethods: As a part of the single-arm, open-label, multicenter, prospective ProLOGUE study (Japan Registry of Clinical Trials identifier: jRCTs031180037), patients were treated with 210 mg of subcutaneous brodalumab in daily clinical practice until week 48. The absolute Psoriasis Area and Severity Index scores and patient-reported outcomes were assessed at baseline and weeks 12 and 48.\nResults: Seventy-three patients (male, 82.2%; median age, 54.0 years) were enrolled. The Dermatology Life Quality Index and European Quality of Life 5-Dimension 5-Level Utility Index scores significantly improved from baseline to weeks 12 and 48. At week 48, all 13 patients with a Dermatology Life Quality Index score of $2 and an absolute Psoriasis Area and Severity Index score of 0 to #2 reported itching.\nLimitations: Unclear generalizability of the results to other biologics.\nConclusion: Treatment with brodalumab improved HRQoL in patients with psoriasis. Itching may contribute to incomplete HRQoL improvement in patients who have achieved clear or almost-clear skin. ( JAAD Int 2022;8:146-53.)","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"© 2022 by the American Academy of Dermatology, Inc. Published by Elsevier Inc."}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"EISSN","subitem_1522646572813":"2666-3287"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"JAAD International"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-09","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"153","bibliographicPageStart":"146","bibliographicVolumeNumber":"8"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1016/j.jdin.2022.06.013"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-07-25"}],"filename":"M_No8p146.pdf","filesize":[{"value":"352 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://u-ryukyu.repo.nii.ac.jp/record/2019953/files/M_No8p146.pdf"},"version_id":"3378d8ed-79d5-4e9b-8d4b-c485e985bcec"}]},"item_title":"Itch as a critical factor in impaired health-related quality of life in patients with plaque psoriasis achieving clear or almost-clear skin: Analysis of the singlearm, open-label, multicenter, prospective ProLOGUE study","item_type_id":"59","owner":"8","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-07-25"},"publish_date":"2023-07-25","publish_status":"0","recid":"2019953","relation_version_is_last":true,"title":["Itch as a critical factor in impaired health-related quality of life in patients with plaque psoriasis achieving clear or almost-clear skin: Analysis of the singlearm, open-label, multicenter, prospective ProLOGUE study"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2023-08-03T05:46:46.446802+00:00"}