{"created":"2024-10-15T07:16:11.255153+00:00","id":2020693,"links":{},"metadata":{"_buckets":{"deposit":"5ae0c463-baae-4cdd-ac4a-ecfd26b7926c"},"_deposit":{"created_by":8,"id":"2020693","owner":"8","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2020693"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02020693","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"control_number":"2020693","item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Relationships of the Surface Charge of Low-Density Lipoprotein (LDL) with the Serum LDL-Cholesterol and Atherosclerosis Levels in a Japanese Population: The DOSANCO Health Study","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Graduate School of Medicine, University of the Ryukyus","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Hokkaido University Faculty of Medicine","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Nakamura, Koshi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Faculty of Pharmaceutical Sciences, Hokkaido University of Science","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Faculty of Health Sciences, Hokkaido University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Takeda, Seiji","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Faculty of Health Sciences, Hokkaido University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Sakurai, Toshihiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Hokkaido University Faculty of Medicine","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Osaka Metropolitan University Graduate School of Human Life Science","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Ukawa, Shigekazu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Hokkaido University Faculty of Medicine","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Public Interest Incorporated Foundation, the Health Care Science Institute","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Okada, Emiko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"The Hokkaido Centre for Family Medicine","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Nakagawa, Takafumi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Suttu Municipal Clinic","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Imae, Akihiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Faculty of Health Sciences, Hokkaido University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Hui, Shu-Ping","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Faculty of Health Sciences, Hokkaido University","affiliationNameLang":"en"}]},{"affiliationNames":[{"affiliationName":"Sapporo University of Health Sciences","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Chiba, Hitoshi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Hokkaido University Faculty of Medicine","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Tamakoshi, Akiko","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-sa/4.0/"},{"subitem_rights":"©2024 Japan Atherosclerosis Society","subitem_rights_language":"en"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Low-density lipoprotein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Surface charge","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Zeta potential","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cholesterol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epidemiology","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Aim: This study investigated the associations of the surface charge of low-density lipoprotein (LDL) with theserum LDL-cholesterol and atherosclerosis levels in a community-based Japanese population.\nMethods: The study had a cross-sectional design and included 409 community residents aged 35-79 years whodid not take medications for dyslipidemia. The potential electric charge of LDL and the zeta potential, whichindicate the surface charge of LDL, were measured by laser Doppler microelectrophoresis. The correlations of thezeta potential of LDL (−mV) with the serum LDL-cholesterol levels (mg/dL), cardio-ankle vascular index (CAVI),and serum h igh-sensitivity C-reactive protein (hsCRP) levels (log-transformed values, mg/L) were examinedusing Pearson's correlation coefficient (r). Linear regression models were constructed to examine these associationsafter adjusting for potential confounding factors.\nResults: A total of 201 subjects with correctly stored samples were included in the primary analysis for zetapotential measurement. An inverse correlation was observed between the LDL zeta potential and the serum LDLcholesterol levels (r=−0.20; p=0.004). This inverse association was observed after adjusting for sex, age, dietarycholesterol intake, smoking status, alcohol intake, body mass index, and the serum levels of the major classes offree fatty acids (standardized β=−6.94; p=0.005). However, the zeta potential of LDL showed almost noassociation with CAVI or the serum hsCRP levels. Similar patterns were observed in the 208 subjects withcompromised samples as well as all the original 409 subjects.\nConclusion: A higher electronegative surface charge of LDL was associated with lower serum LDL-cholesterollevels in the general Japanese population.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Japan Atherosclerosis Society","subitem_publisher_language":"en"},{"subitem_publisher":"日本動脈硬化学会","subitem_publisher_language":"ja"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1340-3478","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"1880-3873","subitem_source_identifier_type":"EISSN"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_source_title":"Journal of Atherosclerosis and Thrombosis","subitem_source_title_language":"en"}]},"item_1617187056579":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-07-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"14","bibliographicPageStart":"1"}]},"item_1617258105262":{"attribute_name":"item_1617258105262","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617351524846":{"attribute_name":"APC","attribute_value_mlt":[{"subitem_apc":"Paid"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://doi.org/10.5551/jat.64961","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-11-05"}],"filename":"N_No1p1.pdf","filesize":[{"value":"534 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2020693/files/N_No1p1.pdf"},"version_id":"550a8e56-92d7-4cb2-96c6-8a4f2b4899f4"}]},"item_title":"Relationships of the Surface Charge of Low-Density Lipoprotein (LDL) with the Serum LDL-Cholesterol and Atherosclerosis Levels in a Japanese Population: The DOSANCO Health Study","item_type_id":"59","owner":"8","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-15"},"publish_date":"2024-10-15","publish_status":"0","recid":"2020693","relation_version_is_last":true,"title":["Relationships of the Surface Charge of Low-Density Lipoprotein (LDL) with the Serum LDL-Cholesterol and Atherosclerosis Levels in a Japanese Population: The DOSANCO Health Study"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2025-02-18T11:40:38.550576+00:00"}