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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Inhibition of heat shock protein-90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells

http://hdl.handle.net/20.500.12000/271
http://hdl.handle.net/20.500.12000/271
6a48a294-c7c2-4549-9188-5625eb20973a
名前 / ファイル ライセンス アクション
IJC_v120n8p1811_fig.pdf IJC_v120n8p1811_fig.pdf
IJC_v120n8p1811.pdf IJC_v120n8p1811.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2007-03-08
タイトル
タイトル Inhibition of heat shock protein-90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells
言語 en
作成者 Kawakami, Hirochika

× Kawakami, Hirochika

en Kawakami, Hirochika

Tomita, Mariko

× Tomita, Mariko

en Tomita, Mariko

Okudaira, Taeko

× Okudaira, Taeko

en Okudaira, Taeko

Chie, Ishikawa

× Chie, Ishikawa

en Chie, Ishikawa

Matsuda, Takehiro

× Matsuda, Takehiro

en Matsuda, Takehiro

Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

Nakazato, Tetsuro

× Nakazato, Tetsuro

en Nakazato, Tetsuro

Taira, Naoya

× Taira, Naoya

en Taira, Naoya

Ohshiro, Kazuiku

× Ohshiro, Kazuiku

en Ohshiro, Kazuiku

Mori, Naoki

× Mori, Naoki

en Mori, Naoki

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Copyright (c) 2007 Wiley-Liss, Inc
主題
言語 en
主題Scheme Other
主題 ATL
言語 en
主題Scheme Other
主題 HTLV-I
言語 en
主題Scheme Other
主題 17-AAG
言語 en
主題Scheme Other
主題 Hsp90
言語 en
主題Scheme Other
主題 client protein
内容記述
内容記述タイプ Other
内容記述 The molecular chaperone Hsp90 is involved in the stabilization and conformational maturation of many signaling proteins that are deregulated in cancers. The geldanamycin derivative 17-AAG is currently tested in clinical trials and known to inhibit the function of Hsp90 and promote the proteasomal degradation of its misfolded client proteins. ATL is a fatal malignancy of T lymphocytes caused by HTLV-I infection and remains incurable. Since Hsp90 is overexpressed in HTLV-I-infected T-cell lines and primary ATL cells, we analyzed the effects of 17-AAG on cell survival, apoptosis and expression of signal transduction proteins. HTLV-I-infected T-cell lines and primary ATL cells were significantly more sensitive to 17-AAG in cell survival assays than normal PBMCs. 17-AAG induced the inhibition of cell cycle and apoptosis. These effects could be mediated by inactivation of NF-B, AP-1 and PI3K/Akt pathways, as well as reduction of expression of proteins involved in the G1-S cell cycle transition and apoptosis. Proteasome inhibition interfered with 17-AAG-mediated signaling proteins depletion. Collectively, our results indicate that 17-AAG suppresses ATL cell survival through, at least in part, destabilization of several client proteins and suggest that 17-AAG is a potentially useful chemotherapeutic agent for ATL.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Wiley-Liss, Inc.
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
識別子
識別子 http://hdl.handle.net/20.500.12000/271
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 10.1002/ijc.22403
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 00207136
収録物識別子タイプ NCID
収録物識別子 AA00680002
収録物名
言語 en
収録物名 International Journal of Cancer
書誌情報
巻 120, 号 8, p. 1811-1820
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