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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway

http://hdl.handle.net/20.500.12000/2608
http://hdl.handle.net/20.500.12000/2608
f3c8f323-b1bf-4007-bfef-cc5dff78c73d
名前 / ファイル ライセンス アクション
BJHv136n3p424-fig.pdf BJHv136n3p424-fig.pdf
BJHv136n3p424.pdf BJHv136n3p424.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2007-12-10
タイトル
タイトル Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway
言語 en
作成者 Ishikawa, Chie

× Ishikawa, Chie

en Ishikawa, Chie

Matsuda, Takehiro

× Matsuda, Takehiro

en Matsuda, Takehiro

Okudaira, Taeko

× Okudaira, Taeko

en Okudaira, Taeko

Tomita, Mariko

× Tomita, Mariko

en Tomita, Mariko

Kawakami, Hirochika

× Kawakami, Hirochika

en Kawakami, Hirochika

Tanaka, Yuetsu

× Tanaka, Yuetsu

en Tanaka, Yuetsu

Masuda, Masato

× Masuda, Masato

en Masuda, Masato

Ohshiro, Kazuiku

× Ohshiro, Kazuiku

en Ohshiro, Kazuiku

Ohta, Takao

× Ohta, Takao

en Ohta, Takao

Mori, Naoki

× Mori, Naoki

en Mori, Naoki

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
言語 en
主題Scheme Other
主題 bisphosphonate
言語 en
主題Scheme Other
主題 incadronate
言語 en
主題Scheme Other
主題 human T-cell leukaemia virus type I
言語 en
主題Scheme Other
主題 adult T-cell leukaemia
言語 en
主題Scheme Other
主題 mevalonate
内容記述
内容記述タイプ Other
内容記述 Anti-resorptive bisphosphonates are used for the treatment of hypercalcemia and bone complications associated with malignancies and osteoporosis, but have also been shown to have anti-tumour effects in various cancers. Adult T-cell leukaemia (ATL) is a fatal T-cell malignancy caused by infection with human T-cell leukaemia virus type I (HTLV-I), and remains incurable. ATL is associated with osteolytic bone lesions and hypercalcemia, which are major factors in the morbidity of ATL. Thus, the search for anti-ATL agents that have both anti-tumour and anti-resorptive activity is warranted. The bisphosphonate agent, incadronate prevented cell growth of HTLV-I-infected T-cell lines and primary ATL cells, but not of non-infected T-cell lines or normal peripheral blood mononuclear cells. Incadronate induced S-phase cell cycle arrest and apoptosis in HTLV-I-infected T-cell lines, and treatment of these cells with substrates of the mevalonate pathway blocked the incadronate-mediated growth suppression. Incadronate also prevented the prenylation of Rap1A protein. These results demonstrated that incadronate-induced growth suppression occurs by interfering with the mevalonate pathway. Importantly, treatment with incadronate reduced tumour formation from an HTLV-I-infected T-cell line, when these cells were inoculated subcutaneously into severe combined immunodeficient mice. These findings suggest that incadronate could be potentially useful for the treatment of ATL.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Blackwell Publishing
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
識別子
識別子 http://hdl.handle.net/20.500.12000/2608
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ URI
関連識別子 http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2141.2006.06445.x
関連識別子
識別子タイプ DOI
関連識別子 10.1111/j.1365-2141.2006.06445.x
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0007-1048
収録物識別子タイプ NCID
収録物識別子 AA00574570
収録物名
言語 en
収録物名 British journal of haematology
書誌情報
巻 136, 号 3, p. 424-432
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