WEKO3
アイテム
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The alkylidene derivatives are both cyclic and enol phosphates, thereby combining some structural features and biological properties of 2-substituted-benzodioxaphosphorin 2-oxides and 2-chloro-1-(substituted-phenol) ethenyl dialkyl phosphate (e. g., the insecticide tetrachlorvinphos). The toxicity and esterase inhibition are attributable to the reactivity of the P-O-aryl bond of salioxon, but the high biological activity of 4-alkylidene derivative is probably due to their action in phosphorylating esterases or proteases by the P-O-ethenyl bond cleavage, because the alkylidene cyclic phosphonates yielded O-(2-alkylketophenyl) O-methyl phenyl phosphonates on alkaline methanolysis.", "subitem_description_type": "Other"}, {"subitem_description": "\u7d00\u8981\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "\u7409\u7403\u5927\u5b66\u8fb2\u5b66\u90e8"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/3995"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "0370-4246"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AN00250548"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "ja", "subitem_1522650091861": "\u7409\u7403\u5927\u5b66\u8fb2\u5b66\u90e8\u5b66\u8853\u5831\u544a"}, {"subitem_1522650068558": "en", "subitem_1522650091861": "The Science Bulletin of the Faculty of Agriculture. University of the Ryukyus"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1983-11-19", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "30", "bibliographicPageEnd": "226", "bibliographicPageStart": "217"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "KJ00000162169.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2003024/files/KJ00000162169.pdf"}, "version_id": "2552a1a0-1b4d-407b-a167-65122f21ab24"}]}, "item_title": "O-(2-Ethylphenyl) O, O-Diphenyl Phosphate \u304b\u3089 4-Alkylidene-1,3,2-benzodioxaphosphorinane 2-Oxide \u985e\u306e\u4ee3\u8b1d\u751f\u6210(\u8fb2\u82b8\u5316\u5b66\u79d1)", "item_type_id": "15", "owner": "1", "path": ["1642837913657", "1642838407312"], "permalink_uri": "http://hdl.handle.net/20.500.12000/3995", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-02-14"}, "publish_date": "2008-02-14", "publish_status": "0", "recid": "2003024", "relation": {}, "relation_version_is_last": true, "title": ["O-(2-Ethylphenyl) O, O-Diphenyl Phosphate \u304b\u3089 4-Alkylidene-1,3,2-benzodioxaphosphorinane 2-Oxide \u985e\u306e\u4ee3\u8b1d\u751f\u6210(\u8fb2\u82b8\u5316\u5b66\u79d1)"], "weko_shared_id": -1}
O-(2-Ethylphenyl) O, O-Diphenyl Phosphate から 4-Alkylidene-1,3,2-benzodioxaphosphorinane 2-Oxide 類の代謝生成(農芸化学科)
http://hdl.handle.net/20.500.12000/3995
http://hdl.handle.net/20.500.12000/3995ea26b216-e5f5-4329-8b03-4af80316c335
| 名前 / ファイル | ライセンス | アクション | |
|---|---|---|---|
KJ00000162169.pdf
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| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2008-02-14 | |||||||||
| タイトル | ||||||||||
| タイトル | O-(2-Ethylphenyl) O, O-Diphenyl Phosphate から 4-Alkylidene-1,3,2-benzodioxaphosphorinane 2-Oxide 類の代謝生成(農芸化学科) | |||||||||
| 言語 | ja | |||||||||
| 作成者 |
多和田, 真吉
× 多和田, 真吉
× Tawata, Shinkichi
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | O-(2-Ethylphenyl) O, O-diphenyl phosphateのラット及びマウス体内での代謝により, 2-ace-tophenyl類, 2-(α-hydroxyethyl)phenol, 及び少量の4-alkylidene-1,3,2-benzodioxaphosphorin 2-oxideが代謝生成される事を^<31>PNMR及びTLC法で確認した。最終産物の4-alkylidene類は環状であると同時にエノールリン酸類の構造も有しており, 2-置換-benzo-dioxaphosphorin 2-oxide(sa-lioxon)及び2-chloro-1-(substituted-phenol)ethenyl dialkyl phosphate(例えば殺虫剤tetra chlorvinphos)の構造的特徴及び生物活性的性質をかね備えている。毒性発現及びエステラーゼ阻害はsalioxonの場合, P-O-aryl結合の反応性によるが, 4-alkylidene類の高い活性発現は, アルカリ加水分解によりP-O-ethenyl結合が切れる事から, おそらくこの部位で酵素をリン酸化するためと思われた。 | |||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | O-(2-Ethylphenyl) O, O-diphenyl phosphate and O, O-di (2-ethylphenyl) phenylphosphonate are metabolized in rats and mice to give its 2-acetophenyl derivatives, 2-(α-hydroxyethyl) phenol, and small amounts of 4-alkylidene-1,3,2-benzodioxaphosphorin 2-oxides. The alkylidene derivatives are both cyclic and enol phosphates, thereby combining some structural features and biological properties of 2-substituted-benzodioxaphosphorin 2-oxides and 2-chloro-1-(substituted-phenol) ethenyl dialkyl phosphate (e. g., the insecticide tetrachlorvinphos). The toxicity and esterase inhibition are attributable to the reactivity of the P-O-aryl bond of salioxon, but the high biological activity of 4-alkylidene derivative is probably due to their action in phosphorylating esterases or proteases by the P-O-ethenyl bond cleavage, because the alkylidene cyclic phosphonates yielded O-(2-alkylketophenyl) O-methyl phenyl phosphonates on alkaline methanolysis. | |||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 紀要論文 | |||||||||
| 出版者 | ||||||||||
| 言語 | ja | |||||||||
| 出版者 | 琉球大学農学部 | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 識別子 | ||||||||||
| 識別子 | http://hdl.handle.net/20.500.12000/3995 | |||||||||
| 識別子タイプ | HDL | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0370-4246 | |||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN00250548 | |||||||||
| 収録物名 | ||||||||||
| 言語 | ja | |||||||||
| 収録物名 | 琉球大学農学部学術報告 | |||||||||
| 書誌情報 |
号 30, p. 217-226, 発行日 1983-11-19 |
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