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  1. 紀要論文
  2. 琉球大学農学部学術報告
  3. 30号
  1. 部局別インデックス
  2. 農学部

O-(2-Ethylphenyl) O, O-Diphenyl Phosphate から 4-Alkylidene-1,3,2-benzodioxaphosphorinane 2-Oxide 類の代謝生成(農芸化学科)

http://hdl.handle.net/20.500.12000/3995
http://hdl.handle.net/20.500.12000/3995
ea26b216-e5f5-4329-8b03-4af80316c335
名前 / ファイル ライセンス アクション
KJ00000162169.pdf KJ00000162169.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2008-02-14
タイトル
タイトル O-(2-Ethylphenyl) O, O-Diphenyl Phosphate から 4-Alkylidene-1,3,2-benzodioxaphosphorinane 2-Oxide 類の代謝生成(農芸化学科)
言語 ja
作成者 多和田, 真吉

× 多和田, 真吉

ja 多和田, 真吉

Tawata, Shinkichi

× Tawata, Shinkichi

en Tawata, Shinkichi

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
内容記述
内容記述タイプ Other
内容記述 O-(2-Ethylphenyl) O, O-diphenyl phosphateのラット及びマウス体内での代謝により, 2-ace-tophenyl類, 2-(α-hydroxyethyl)phenol, 及び少量の4-alkylidene-1,3,2-benzodioxaphosphorin 2-oxideが代謝生成される事を^<31>PNMR及びTLC法で確認した。最終産物の4-alkylidene類は環状であると同時にエノールリン酸類の構造も有しており, 2-置換-benzo-dioxaphosphorin 2-oxide(sa-lioxon)及び2-chloro-1-(substituted-phenol)ethenyl dialkyl phosphate(例えば殺虫剤tetra chlorvinphos)の構造的特徴及び生物活性的性質をかね備えている。毒性発現及びエステラーゼ阻害はsalioxonの場合, P-O-aryl結合の反応性によるが, 4-alkylidene類の高い活性発現は, アルカリ加水分解によりP-O-ethenyl結合が切れる事から, おそらくこの部位で酵素をリン酸化するためと思われた。
内容記述タイプ Other
内容記述 O-(2-Ethylphenyl) O, O-diphenyl phosphate and O, O-di (2-ethylphenyl) phenylphosphonate are metabolized in rats and mice to give its 2-acetophenyl derivatives, 2-(α-hydroxyethyl) phenol, and small amounts of 4-alkylidene-1,3,2-benzodioxaphosphorin 2-oxides. The alkylidene derivatives are both cyclic and enol phosphates, thereby combining some structural features and biological properties of 2-substituted-benzodioxaphosphorin 2-oxides and 2-chloro-1-(substituted-phenol) ethenyl dialkyl phosphate (e. g., the insecticide tetrachlorvinphos). The toxicity and esterase inhibition are attributable to the reactivity of the P-O-aryl bond of salioxon, but the high biological activity of 4-alkylidene derivative is probably due to their action in phosphorylating esterases or proteases by the P-O-ethenyl bond cleavage, because the alkylidene cyclic phosphonates yielded O-(2-alkylketophenyl) O-methyl phenyl phosphonates on alkaline methanolysis.
内容記述タイプ Other
内容記述 紀要論文
出版者
言語 ja
出版者 琉球大学農学部
言語
言語 eng
資源タイプ
資源タイプ departmental bulletin paper
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/3995
識別子タイプ HDL
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0370-4246
収録物識別子タイプ NCID
収録物識別子 AN00250548
収録物名
言語 ja
収録物名 琉球大学農学部学術報告
書誌情報
号 30, p. 217-226
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