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Cell signaling modifiers for molecular targeted therapy in ATLL
http://hdl.handle.net/20.500.12000/10327
http://hdl.handle.net/20.500.12000/103272323d0fe-b5e0-4e18-ae1d-a50e0d6febe0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Mori.Fig.pdf
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Mori.pdf
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| Item type | デフォルトアイテムタイプ（フル）(1) | |||||||
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| 公開日 | 2009-05-29 | |||||||
| タイトル | ||||||||
| タイトル | Cell signaling modifiers for molecular targeted therapy in ATLL | |||||||
| 言語 | en | |||||||
| 作成者 |
Mori, Naoki
× Mori, Naoki
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Adult T-cell leukemia/lymphoma | |||||||
| 主題 | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Human T-cell leukemia virus type 1 | |||||||
| 主題 | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Signal transduction | |||||||
| 主題 | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Apoptosis | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Adult T-cell leukemia/lymphoma (ATTL) is a malignancy of peripheral T lymphocytes caused by human T-cell leukemia virus type 1 (HTLV-1) infection. Available therapies for ATLL have minimal efficacy, with few responders and poor survival. New therapies are clearly needed for ATTL patients. Three decades of research in this field has resulted in accumulation of a wealth of knowledge about the molecular pathways underlying the proliferation of HTLV-1-infected T cells. Inappropriate over- and under-activation of various signaling pathways can contribute to pathological processes such as neoplasia. Molecular and pharmacological interventions that target the aberrant state of activation are thus of potential therapeutic benefit. Here we review how signal transduction pathway components including nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1), janus kinase-signal transducer and activator of transcription (JAK-STAT), and phosphatidylinositol 3-kinase (PI3K)-Akt contribute to the pathogenesis of ATLL. The targeted inhibition of such molecules to suppress the growth of HTLV-1-infected T cells both in vitro and in vivo is also discussed. The potential translation of such strategies into effective therapies for patients with ATLL may improve the poor outcome associated with this neoplasia. | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 論文 | |||||||
| 出版者 | ||||||||
| 出版者 | Frontiers in Bioscience Publications | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 識別子 | ||||||||
| 識別子 | http://hdl.handle.net/20.500.12000/10327 | |||||||
| 識別子タイプ | HDL | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://dx.doi.org/10.2741/3319 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.2741/3321 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 19273141 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 1093-9946 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA11735423 | |||||||
| 収録物名 | ||||||||
| 収録物名 | Frontiers in Bioscience | |||||||
| 言語 | en | |||||||
| 書誌情報 |
巻 14, p. 1479-1489, 発行日 2009-01-01 |
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