{"_buckets": {"deposit": "b3f102e3-fe16-4cd2-8ced-2f6062a2f9c5"}, "_deposit": {"id": "2004789", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2004789"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02004789", "sets": ["1642838403123", "1642838407795"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "HTLV-I感染によるM期チェックポイント異常とATL治療への応用", "subitem_1551255648112": "ja"}, {"subitem_1551255647225": "Dysregulation of mitotic checkpoint by infection with HTLV-I", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "富田, 真理子", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "Tomita, Mariko", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186609386": {"attribute_name": "Subject", "attribute_value_mlt": [{"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "ウイルス"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "癌"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "感染症"}, {"subitem_1522299896455": "ja", "subitem_1522300014469": "Other", "subitem_1523261968819": "シグナル伝達"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "科研費番号: 19591122", "subitem_description_type": "Other"}, {"subitem_description": "2007年度～2008年度科学研究費補助金（基盤研究(C)）研究成果報告書", "subitem_description_type": "Other"}, {"subitem_description": "研究概要：ヒトT細胞白血病ウイルスⅠ型（HTLV-I）感染細胞における細胞分裂期(M期)チェックポイント異常の分子機構を解明し，成人T細胞白血病（ATL）治療の標的となるかを明らかにすることを目的とし本研究を行った．我々は，HTLV-I感染T細胞株やATL細胞において，M期チェックポイント遺伝子の一つであるCHFRの発現が異常メチル化により抑制され，これにより細胞の異常増殖がもたらされることを明らかにした．この分子機構をCHFRのユビキチン化標的蛋白質であるAurora Aに焦点を当てて解析した結果，CHFR発現抑制によりHTLV-I感染T細胞ではAurora Aが高発現していること，さらに，siRNAによるAurora AのノックダウンもしくはAuroraキナーゼ阻害剤処理により，HTLV-I感染T細胞の増殖・生存を阻害した．以上の結果より，CHFRおよびAurora AはATL治療の標的となりうることが明らかとなった．", "subitem_description_type": "Other"}, {"subitem_description": "研究報告書", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "ja", "subitem_1522300316516": "富田真理子"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "jpn"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/11752"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-05-28", "bibliographicIssueDateType": "Issued"}}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "AM", "subitem_1600292170262": "http://purl.org/coar/version/c_ab4af688f83e57aa"}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "19591122seika.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2004789/files/19591122seika.pdf"}, "version_id": "bb628386-3916-4e39-8c56-a9daa4e80a4b"}]}, "item_title": "HTLV-I感染によるM期チェックポイント異常とATL治療への応用", "item_type_id": "15", "owner": "1", "path": ["1642838403123", "1642838407795"], "permalink_uri": "http://hdl.handle.net/20.500.12000/11752", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2009-08-11"}, "publish_date": "2009-08-11", "publish_status": "0", "recid": "2004789", "relation": {}, "relation_version_is_last": true, "title": ["HTLV-I感染によるM期チェックポイント異常とATL治療への応用"], "weko_shared_id": -1}