{"_buckets": {"deposit": "8a3a2111-6107-476b-b03c-dd373b5783eb"}, "_deposit": {"id": "2004904", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2004904"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02004904", "sets": ["1642838338003", "1642838407795"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Anti-adult T-cell leukemia effects of a novel synthetic retinoid, Am80 (Tamibarotene)", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakazato, Tetsuro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Okudaira, Taeko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Chie", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nakama, Shinji", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sawada, Shigeki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tomita, Mariko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Uchihara, Jun-nosuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Taira, Naoya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Masuda, Masato", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tanaka, Yuetsu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohshiro, Kazuiku", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takasu, Nobuyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mori, Naoki", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Clinical trials for treatment of adult T-cell leukemia (ATL) caused by human T-cell leukemia virus type I (HTLV-I) using all-trans-retinoic acid (ATRA) have shown satisfactory therapeutic responses, although efficacies were limited. Recently, many synthetic retinoids have been developed and among them, a novel synthetic retinoid, Am80 (Tamibarotene) is an RARα- and RARβ-specific retinoid expected to overcome ATRA resistance. The present study examined the inhibitory effects of Am80 on HTLV-I-infected T-cell lines and ATL cells. Am80 had negligible growth inhibition of peripheral blood mononuclear cells but marked growth inhibition of both HTLV-I-infected T-cell lines and ATL cells. Am80 arrested cells in the G1 phase of the cell cycle and induced apoptosis in HTLV-I-infected T-cell lines. It inhibited also the phosphorylation of IκBα and NF-κB-DNA binding, in conjunction with reduction of expression of proteins involved in the G1/S cell cycle transition and apoptosis. Am80 also inhibited the expression of JunD, resulting in suppression of AP-1-DNA binding. Furthermore, severe combined immunodeficient mice with tumors induced by subcutaneous inoculation of HTLV-I-infected T cells, responded to Am80 treatment with partial regression of tumors and no side-effects. These findings demonstrate that Am80 is a potential inhibitor of NF-κB and AP-1, and is a potentially useful therapeutic agent against ATL. (Cancer Sci 2008; 99: 2286–2294)", "subitem_description_type": "Other"}, {"subitem_description": "論文", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "en", "subitem_1522300316516": "Blackwell Publishing"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/12747"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1347-9032"}, {"subitem_1522646500366": "NCID", "subitem_1522646572813": "AA11808050"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "Cancer Science"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "2294", "bibliographicPageStart": "2286", "bibliographicVolumeNumber": "99"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "AM", "subitem_1600292170262": "http://purl.org/coar/version/c_ab4af688f83e57aa"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "URI", "subitem_1522306436033": "http://www.blackwell-synergy.com/doi/abs/10.1111/j.1349-7006.2008.00917.x"}}, {"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "10.1111/j.1349-7006.2008.00917.x"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "0382-2008Fig.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2004904/files/0382-2008Fig.pdf"}, "version_id": "4f99e2ee-0ace-4f8d-ae0a-e581cb0f2278"}, {"accessrole": "open_access", "download_preview_message": "", "file_order": 1, "filename": "0382-2008.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2004904/files/0382-2008.pdf"}, "version_id": "5c0a933f-a280-4d86-9306-53cfeb971c13"}]}, "item_title": "Anti-adult T-cell leukemia effects of a novel synthetic retinoid, Am80 (Tamibarotene)", "item_type_id": "15", "owner": "1", "path": ["1642838338003", "1642838407795"], "permalink_uri": "http://hdl.handle.net/20.500.12000/12747", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2009-10-19"}, "publish_date": "2009-10-19", "publish_status": "0", "recid": "2004904", "relation": {}, "relation_version_is_last": true, "title": ["Anti-adult T-cell leukemia effects of a novel synthetic retinoid, Am80 (Tamibarotene)"], "weko_shared_id": -1}
Anti-adult T-cell leukemia effects of a novel synthetic retinoid, Am80 (Tamibarotene)
http://hdl.handle.net/20.500.12000/12747
http://hdl.handle.net/20.500.12000/12747