Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2009-10-19 |
タイトル |
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タイトル |
Anti-adult T-cell leukemia effects of a novel synthetic retinoid, Am80 (Tamibarotene) |
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言語 |
en |
作成者 |
Nakazato, Tetsuro
Okudaira, Taeko
Ishikawa, Chie
Nakama, Shinji
Sawada, Shigeki
Tomita, Mariko
Uchihara, Jun-nosuke
Taira, Naoya
Masuda, Masato
Tanaka, Yuetsu
Ohshiro, Kazuiku
Takasu, Nobuyuki
Mori, Naoki
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Clinical trials for treatment of adult T-cell leukemia (ATL) caused by human T-cell leukemia virus type I (HTLV-I) using all-trans-retinoic acid (ATRA) have shown satisfactory therapeutic responses, although efficacies were limited. Recently, many synthetic retinoids have been developed and among them, a novel synthetic retinoid, Am80 (Tamibarotene) is an RARα- and RARβ-specific retinoid expected to overcome ATRA resistance. The present study examined the inhibitory effects of Am80 on HTLV-I-infected T-cell lines and ATL cells. Am80 had negligible growth inhibition of peripheral blood mononuclear cells but marked growth inhibition of both HTLV-I-infected T-cell lines and ATL cells. Am80 arrested cells in the G1 phase of the cell cycle and induced apoptosis in HTLV-I-infected T-cell lines. It inhibited also the phosphorylation of IκBα and NF-κB-DNA binding, in conjunction with reduction of expression of proteins involved in the G1/S cell cycle transition and apoptosis. Am80 also inhibited the expression of JunD, resulting in suppression of AP-1-DNA binding. Furthermore, severe combined immunodeficient mice with tumors induced by subcutaneous inoculation of HTLV-I-infected T cells, responded to Am80 treatment with partial regression of tumors and no side-effects. These findings demonstrate that Am80 is a potential inhibitor of NF-κB and AP-1, and is a potentially useful therapeutic agent against ATL. (Cancer Sci 2008; 99: 2286–2294) |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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出版者 |
Blackwell Publishing |
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言語 |
en |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/12747 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
URI |
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関連識別子 |
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1349-7006.2008.00917.x |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
10.1111/j.1349-7006.2008.00917.x |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1347-9032 |
収録物識別子 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11808050 |
収録物名 |
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収録物名 |
Cancer Science |
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言語 |
en |
書誌情報 |
巻 99,
号 11,
p. 2286-2294,
発行日 2008-11
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