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  1. その他
  1. 部局別インデックス
  2. 医学部

有機リン系農薬の体内動態解析 -CE-MSによる代謝物分析法の開発と応用-

http://hdl.handle.net/20.500.12000/17850
http://hdl.handle.net/20.500.12000/17850
17887512-b3bd-4e2b-9c09-e9f9dd5e6212
名前 / ファイル ライセンス アクション
19590678seika.pdf 19590678seika.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-08-10
タイトル
タイトル 有機リン系農薬の体内動態解析 -CE-MSによる代謝物分析法の開発と応用-
言語 ja
作成者 福家, 千昭

× 福家, 千昭

ja 福家, 千昭

Fuke, Chiaki

× Fuke, Chiaki

en Fuke, Chiaki

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
言語 ja
主題Scheme Other
主題 キャピラリー電気泳動質量分析法
言語 ja
主題Scheme Other
主題 有機リン系農薬
言語 ja
主題Scheme Other
主題 代謝物
言語 ja
主題Scheme Other
主題 生体試料
言語 ja
主題Scheme Other
主題 中毒
内容記述
内容記述タイプ Other
内容記述 科研費番号: 19590678
内容記述タイプ Other
内容記述 2007年度~2009年度科学研究費補助金(基盤研究(C))研究成果報告書
内容記述タイプ Other
内容記述 研究概要(和文):有機リン系農薬の分解物であるジアルキルフォスフェート(DAP)のキャピラリー電気泳動質量分析計(CE-MS)による定量分析法の開発を行い,実試料に応用した.CE-MSにより有機リン系代謝物のうち7種のDAPの定量分析が可能であった.全ての有機リン系農薬中毒患者で,予想されるDAPが検出された.さらにO,S-ジメチルチオフォスフェートというこれまでに報告のない新規の代謝物を検出した.DAPを定量することにより,摂取した有機リン系農薬のタイプや単独製剤と混合製剤の判別が可能で,ジメチルフォスフェート濃度と中毒症状の重さとの間に相関傾向をみいだすことができた.
内容記述タイプ Other
内容記述 研究概要(英文) : We developed a determination method for the dialkylphosphates (DAPs), metabolites of organophosphate insecticides, using capillary electrophoresis / mass spectrometer (CE/MS) and applied this method to serum and urine collected from poisoned patients with organophosphate insecticide. The 7 DAPs were detected by CE-MS. In all of 29 caces of organophosphate insecticide poisoning, the expected DAPs were detected using this method. O,S-DMTP was also detected. The phosphate type and single or mix formulation of ingested organophosphate insecticide could be distinguished by determination of DAPs. There was a relation between DMP concentration in the serum and the degree of toxic symptoms.
内容記述タイプ Other
内容記述 研究報告書
出版者
言語 ja
出版者 福家千昭
言語
言語 jpn
資源タイプ
資源タイプ research report
資源タイプ識別子 http://purl.org/coar/resource_type/c_18ws
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
識別子
識別子 http://hdl.handle.net/20.500.12000/17850
識別子タイプ HDL
書誌情報
発行日 2010-05-20
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