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  1. 部局別インデックス
  2. 医学部

脊髄虚血後モルヒネ誘発痙性対麻痺の機序解明に関する研究~一酸化窒素の関与~

http://hdl.handle.net/20.500.12000/17887
http://hdl.handle.net/20.500.12000/17887
18bce722-3516-48ec-a69d-37a0b7355b9c
名前 / ファイル ライセンス アクション
19591809seika.pdf 19591809seika.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2010-08-11
タイトル
タイトル 脊髄虚血後モルヒネ誘発痙性対麻痺の機序解明に関する研究~一酸化窒素の関与~
言語 ja
作成者 垣花, 学

× 垣花, 学

ja 垣花, 学

中村, 清哉

× 中村, 清哉

ja 中村, 清哉

斎川, 仁子

× 斎川, 仁子

ja 斎川, 仁子

比嘉, 達也

× 比嘉, 達也

ja 比嘉, 達也

Kakinohana, Manabu

× Kakinohana, Manabu

en Kakinohana, Manabu

Nakamura, Seiya

× Nakamura, Seiya

en Nakamura, Seiya

Saikawa, Satoko

× Saikawa, Satoko

en Saikawa, Satoko

Higa, Tatsuya

× Higa, Tatsuya

en Higa, Tatsuya

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
言語 ja
主題Scheme Other
主題 対麻痺
言語 ja
主題Scheme Other
主題 脊髄虚血
言語 ja
主題Scheme Other
主題 オピオイド
言語 ja
主題Scheme Other
主題 一酸化窒素
言語 ja
主題Scheme Other
主題 痙性対麻痺
言語 ja
主題Scheme Other
主題 モルヒネ
言語 ja
主題Scheme Other
主題 麻薬
内容記述
内容記述タイプ Other
内容記述 科研費番号: 19591809
内容記述タイプ Other
内容記述 2007年度~2009年度科学研究費補助金(基盤研究(C))研究成果報告書
内容記述タイプ Other
内容記述 研究概要(和文):ラット脊髄虚血モデルを用い脊髄虚血後くも膜下モルヒネ投与による痙性対麻痺への一酸化窒素の関与について検討した。モルヒネ30mg (M群)では投与後2時間から対麻痺となりその後運動機能は回復しなかった。一方、モルヒネとODQ (MI群)では対麻痺となることはなく投与後72時間目で歩行可能であった。ラット脊髄虚血後くも膜下モルヒネによる痙性対麻痺にモルヒネ-NO-sGC-cGMPという反応系の重要性が確認された。
内容記述タイプ Other
内容記述 研究概要(英文):Our previous study showed that opioid receptor activation even after short-lasting spinal cord ischemia in the rat could cause irreversible paraplegia. This study elucidated the relationship between nitric oxide and morhine inducing paraplegia after spinal cord ischemia. While IT morphine alone could induce irreversible paraplegia, the combination between IT morphine and ODQ failed to induce neurological deficit. Our results suggested that nitric oxide-guanylate cyclase-cGMP pathway should be involved in the inducing paraplegia.
内容記述タイプ Other
内容記述 研究報告書
出版者
言語 ja
出版者 垣花学
言語
言語 jpn
資源タイプ
資源タイプ research report
資源タイプ識別子 http://purl.org/coar/resource_type/c_18ws
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
識別子
識別子 http://hdl.handle.net/20.500.12000/17887
識別子タイプ HDL
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