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  1. 学位論文
  2. 博士論文
  3. 医学研究科
  1. 部局別インデックス
  2. 医学研究科

拡大肝切除時に網内系賦活剤の投与や脾摘の意義に関する実験的研究

http://hdl.handle.net/20.500.12000/25398
http://hdl.handle.net/20.500.12000/25398
879e0dc4-274f-4bcf-9a03-89222590e706
名前 / ファイル ライセンス アクション
000000410274.pdf 000000410274.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2021-12-15
タイトル
タイトル 拡大肝切除時に網内系賦活剤の投与や脾摘の意義に関する実験的研究
言語 ja
作成者 宮良, 球一郎

× 宮良, 球一郎

ja 宮良, 球一郎

Miyara, Kyuichirou

× Miyara, Kyuichirou

en Miyara, Kyuichirou

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
言語 en
主題Scheme Other
主題 93%hepatectomy
言語 en
主題Scheme Other
主題 OK-432
言語 en
主題Scheme Other
主題 splenectomy
言語 en
主題Scheme Other
主題 reticuloendotherial function
内容記述
内容記述タイプ Other
内容記述 報告番号(甲第54号)
内容記述タイプ Other
内容記述 The purpose of this study is to evaluate the influence of increased activity of reticuloecndothelial-function by OK-432 and splenectomy on hepatic regeneration following 93% hepatectomy in rats. Wister male rats weighting 240g to 320g were randomly allocated to 4 experimental groups and subjected to the following regimen : (1) A group; 93% hepatectomy alone, (2) B group; 93% hepatectomy + splenectomy, (3) C group; OK-432 + 93% hepatectomy, (4) D group; OK-432 + 93% hepatectomy + splenectomy. Survival rates after hepatectomy, initial, 24hour, 48hour, serum endotoxin, S-GOT, S-GPT in each group were determined. The long-term (180 days following hepatectomy) survival rates was 45.5% in A group, 13.6% in B group, 6.4% in C group and 6.3% in D group. respectively and A group survival was statistically significant bellter compared with other three groups. Serum endotoxin titers prior to hepatectomy were significantly lower (0.926 pg/ml) in OK-432 treated groups than in non-treated groups (3.3 pg/ml). 24hours after hepatcctomy, A group showed marked increase titers of endotoxin with statistical significance compared with other three groups. S-GOT and S-GPT markedly elevated 24hours after hepatectomy, but returned to the normal values 48hours after hepatectomy. These results might suggest that in 93% experimental hepatectomy in rats, activation of reticuloendotherial function could be harmful in liver regeneration after hepatectomy, and lower survival rate from the long-term survival points, therefore, anothter unknown mechanism might play an important role in liver damagt after hepatectomy.
内容記述タイプ Other
内容記述 学位論文
出版者
言語 ja
出版者 宮良球一郎
言語
言語 jpn
資源タイプ
資源タイプ doctoral thesis
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/25398
識別子タイプ HDL
関連情報
関連名称
言語 ja
関連名称 琉球医学会誌=Ryukyu Medical Journal.12巻1号(1992)
学位名
学位名 博士(医学)
言語 ja
学位授与年月日
学位授与年月日 1993-04-26
学位授与機関
学位授与機関識別子
学位授与機関識別子 18001
学位授与機関識別子Scheme kakenhi
学位授与機関名
学位授与機関名 琉球大学
言語 ja
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