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  1. 学位論文
  2. 博士論文
  3. 医学研究科
  1. 部局別インデックス
  2. 医学研究科

末梢神経急性圧迫障害に対する薬物療法の有効性に関する実験的研究

http://hdl.handle.net/20.500.12000/25399
http://hdl.handle.net/20.500.12000/25399
d8ed7c21-c304-4f86-87ac-6afbfb04bd5b
名前 / ファイル ライセンス アクション
000000410477.pdf 000000410477.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2021-12-15
タイトル
タイトル 末梢神経急性圧迫障害に対する薬物療法の有効性に関する実験的研究
言語 ja
作成者 武内, 正典

× 武内, 正典

ja 武内, 正典

Takeuchi, Masanori

× Takeuchi, Masanori

en Takeuchi, Masanori

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
言語 en
主題Scheme Other
主題 steroids
言語 en
主題Scheme Other
主題 non steroideal antiinflammatory drugs (NSAIDs)
言語 en
主題Scheme Other
主題 peripheral nerve
言語 en
主題Scheme Other
主題 acute compression injury
言語 en
主題Scheme Other
主題 Sciatic Functional Index (SFI)
内容記述
内容記述タイプ Other
内容記述 報告番号(乙第39号)
内容記述タイプ Other
内容記述 Steroids and nun-steroideal antiinflammatory drugs (NSAIDs) are often administered clinically for the treatment of nerve compression injury. The present study dealt with evaluation of the effect of steroids, NSAIDs (cyclooxygenase inhibitor) and Takeda AA-861 (lipoxygenase inhibitor) on the function, using the sciatic functional indx, histology and microcirculatiun of the rat sciatic nerves following compressin. The sciatic nerve of rats wrapped with a silicone tube with appropriate internal diameter caused a compression to the nerve. It was found that steroid therapy can prevent the functional impairment caused by compression. Silicone rubber injection into the artery of the rat sciatic nerve revealed the situation of vascular impairment. The edema occured in the epineurium was prevented by steroid administration. Following epineurectomy and application of silicone tube. this recovery was not recognized although steroid was given. NSAIDs (cyclooxygenase inhibitor) and/or Takeda AA-861 (lypoxigenase inhibitor) failed to have any benifical effect. Therefore it would be concluded that acute compression nerve palsy) is caused by ederna at epineurium and the utilization of steroid is effective to prevent dysfunction due to the extrapathway of arachidonic acid metabolism in inflammatory system.
内容記述タイプ Other
内容記述 学位論文
出版者
言語 ja
出版者 武内正典
言語
言語 jpn
資源タイプ
資源タイプ doctoral thesis
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/25399
識別子タイプ HDL
関連情報
関連名称
言語 ja
関連名称 日本手の外科学会雑誌.第10巻第6号(1994)
学位名
学位名 博士(医学)
言語 ja
学位授与年月日
学位授与年月日 1994-03-18
学位授与機関
学位授与機関識別子
学位授与機関識別子 18001
学位授与機関識別子Scheme kakenhi
学位授与機関名
学位授与機関名 琉球大学
言語 ja
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