Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2018-01-18 |
タイトル |
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タイトル |
Effect of Mukitake mushroom (Panellus serotinus) on the pathogenesis of lipid abnormalities in obese, diabetic ob/ob mice. |
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言語 |
en |
作成者 |
Inoue, Nao
Inafuku, Masashi
Shirouchi, Bungo
Nagao, Koji
Yanagita, Teruyoshi
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Panellus serotinus |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Atherogenic index |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Nonalcoholic fatty acid disease |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
ob/ob mice |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Background: Various mushrooms have been used in folk medicine for the treatment of lifestyle diseases in eastern countries, and several compounds that modulate the immune system, lower blood lipid levels, and inhibit tumor and viral action have been isolated. The fruiting body of Panellus serotinus (Mukitake) is recognized in Japan as one of the most delicious edible mushrooms, and previous studies have demonstrated that the dietary intake of powdered whole Mukitake or Mukitake extracts prevents the development of non-alcoholic fatty liver disease (NAFLD) in leptin-resistant db/db mice. In the present study, we evaluated the effect of the Mukitake diet on the pathogenesis of metabolic disorders in leptin-deficient ob/ob mice. Results: After 4 weeks of feeding, hepatomegaly, hepatic lipid accumulation, and elevated hepatic injury markers in the serum were markedly alleviated in Mukitake-fed ob/ob mice compared with control mice. Moreover, the mild hyperlipidemia in control ob/ob mice was attenuated and the elevated atherogenic index was reduced in Mukitake-fed ob/ob mice. These effects were partly attributable to the suppression of hepatic lipogenic enzyme activity due to the Mukitake diet. Conclusion: The current results showed that Mukitake supplementation is beneficial for the alleviation of NAFLD and dyslipidemia in obese, diabetic ob/ob mice |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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言語 |
en |
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出版者 |
BioMed Central |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ |
journal article |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
出版タイプ |
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出版タイプ |
NA |
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出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/37588 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1186/1476-511X-12-18 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
info:doi/10.1186/1476-511X-12-18 |
関連情報 |
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識別子タイプ |
PMID |
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関連識別子 |
23406154 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1476-511X |
収録物名 |
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言語 |
en |
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収録物名 |
Lipids in Health and Disease |
書誌情報 |
巻 12,
p. 18-23,
発行日 2013-02-14
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