Item type |
デフォルトアイテムタイプ(フル)(1) |
公開日 |
2020-10-14 |
タイトル |
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タイトル |
Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association With Oral Immunological Biomarkers |
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言語 |
en |
作成者 |
Said, Heba S.
Suda, Wataru
Nakagome, Shigeki
Chinen, Hiroshi
Oshima, Kenshiro
Kim, Sangwan
Kimura, Ryosuke
Iraha, Atsushi
Ishida, Hajime
Fujita, Jiro
Mano, Shuhei
Morita, Hidetoshi
Dohi, Taeko
Oota, Hiroki
Hattori, Masahira
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利情報 |
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言語 |
en |
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権利情報 |
Creative Commons Attribution 3.0 right |
権利情報 |
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言語 |
en |
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権利情報Resource |
https://creativecommons.org/licenses/by/3.0/ |
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権利情報 |
https://creativecommons.org/licenses/by/3.0/ |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Crohn's disease |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
ulcerative colitis |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
salivary microbiota |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
16S rRNA |
主題 |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
pyrosequencing |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Analysis of microbiota in various biological and environmental samples under a variety of conditions has recently become more practical due to remarkable advances in next-generation sequencing. Changes leading to specific biological states including some of the more complex diseases can now be characterized with relative ease. It is known that gut microbiota is involved in the pathogenesis of inflammatory bowel disease (IBD), mainly Crohn's disease and ulcerative colitis, exhibiting symptoms in the gastrointestinal tract. Recent studies also showed increased frequency of oral manifestations among IBD patients, indicating aberrations in the oral microbiota. Based on these observations, we analyzed the composition of salivary microbiota of 35 IBD patients by 454 pyrosequencing of the bacterial 16S rRNA gene and compared it with that of 24 healthy controls (HCs). The results showed that Bacteroidetes was significantly increased with a concurrent decrease in Proteobacteria in the salivary microbiota of IBD patients. The dominant genera, Streptococcus, Prevotella, Neisseria, Haemophilus, Veillonella, and Gemella, were found to largely contribute to dysbiosis (dysbacteriosis) observed in the salivary microbiota of IBD patients. Analysis of immunological biomarkers in the saliva of IBD patients showed elevated levels of many inflammatory cytokines and immunoglobulin A, and a lower lysozyme level. A strong correlation was shown between lysozyme and IL-1β levels and the relative abundance of Streptococcus, Prevotella, Haemophilus and Veillonella. Our data demonstrate that dysbiosis of salivary microbiota is associated with inflammatory responses in IBD patients, suggesting that it is possibly linked to dysbiosis of their gut microbiota. |
内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
論文 |
出版者 |
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出版者 |
Oxford University Press |
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言語 |
en |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
識別子 |
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識別子 |
http://hdl.handle.net/20.500.12000/46980 |
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識別子タイプ |
HDL |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1093/dnares/dst037 |
関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1093/dnares/dst037 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1340-2838 |
収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1756-1663 |
収録物名 |
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収録物名 |
DNA Research |
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言語 |
en |
書誌情報 |
巻 21,
号 1,
p. 15-25,
発行日 2013-09-07
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