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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association With Oral Immunological Biomarkers

http://hdl.handle.net/20.500.12000/46980
http://hdl.handle.net/20.500.12000/46980
077e5a69-4a0e-43f1-8a1b-c0f77e784091
名前 / ファイル ライセンス アクション
dst037.pdf dst037.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-10-14
タイトル
タイトル Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association With Oral Immunological Biomarkers
言語 en
作成者 Said, Heba S.

× Said, Heba S.

en Said, Heba S.

Suda, Wataru

× Suda, Wataru

en Suda, Wataru

Nakagome, Shigeki

× Nakagome, Shigeki

en Nakagome, Shigeki

Chinen, Hiroshi

× Chinen, Hiroshi

en Chinen, Hiroshi

Oshima, Kenshiro

× Oshima, Kenshiro

en Oshima, Kenshiro

Kim, Sangwan

× Kim, Sangwan

en Kim, Sangwan

Kimura, Ryosuke

× Kimura, Ryosuke

en Kimura, Ryosuke

Iraha, Atsushi

× Iraha, Atsushi

en Iraha, Atsushi

Ishida, Hajime

× Ishida, Hajime

en Ishida, Hajime

Fujita, Jiro

× Fujita, Jiro

en Fujita, Jiro

Mano, Shuhei

× Mano, Shuhei

en Mano, Shuhei

Morita, Hidetoshi

× Morita, Hidetoshi

en Morita, Hidetoshi

Dohi, Taeko

× Dohi, Taeko

en Dohi, Taeko

Oota, Hiroki

× Oota, Hiroki

en Oota, Hiroki

Hattori, Masahira

× Hattori, Masahira

en Hattori, Masahira

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution 3.0 right
言語 en
権利情報Resource https://creativecommons.org/licenses/by/3.0/
権利情報 https://creativecommons.org/licenses/by/3.0/
主題
言語 en
主題Scheme Other
主題 Crohn's disease
言語 en
主題Scheme Other
主題 ulcerative colitis
言語 en
主題Scheme Other
主題 salivary microbiota
言語 en
主題Scheme Other
主題 16S rRNA
言語 en
主題Scheme Other
主題 pyrosequencing
内容記述
内容記述タイプ Other
内容記述 Analysis of microbiota in various biological and environmental samples under a variety of conditions has recently become more practical due to remarkable advances in next-generation sequencing. Changes leading to specific biological states including some of the more complex diseases can now be characterized with relative ease. It is known that gut microbiota is involved in the pathogenesis of inflammatory bowel disease (IBD), mainly Crohn's disease and ulcerative colitis, exhibiting symptoms in the gastrointestinal tract. Recent studies also showed increased frequency of oral manifestations among IBD patients, indicating aberrations in the oral microbiota. Based on these observations, we analyzed the composition of salivary microbiota of 35 IBD patients by 454 pyrosequencing of the bacterial 16S rRNA gene and compared it with that of 24 healthy controls (HCs). The results showed that Bacteroidetes was significantly increased with a concurrent decrease in Proteobacteria in the salivary microbiota of IBD patients. The dominant genera, Streptococcus, Prevotella, Neisseria, Haemophilus, Veillonella, and Gemella, were found to largely contribute to dysbiosis (dysbacteriosis) observed in the salivary microbiota of IBD patients. Analysis of immunological biomarkers in the saliva of IBD patients showed elevated levels of many inflammatory cytokines and immunoglobulin A, and a lower lysozyme level. A strong correlation was shown between lysozyme and IL-1β levels and the relative abundance of Streptococcus, Prevotella, Haemophilus and Veillonella. Our data demonstrate that dysbiosis of salivary microbiota is associated with inflammatory responses in IBD patients, suggesting that it is possibly linked to dysbiosis of their gut microbiota.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/46980
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/dnares/dst037
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/dnares/dst037
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1340-2838
収録物識別子タイプ ISSN
収録物識別子 1756-1663
収録物名
言語 en
収録物名 DNA Research
書誌情報
巻 21, 号 1, p. 15-25
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