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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Polymorphisms associated with a tropical climate and root crop diet induce susceptibility to metabolic and cardiovascular diseases in Solomon Islands

http://hdl.handle.net/20.500.12000/47014
http://hdl.handle.net/20.500.12000/47014
216db685-ad8c-436a-8172-008488fb3496
名前 / ファイル ライセンス アクション
journal.pone.0172676.pdf journal.pone.0172676.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-10-20
タイトル
タイトル Polymorphisms associated with a tropical climate and root crop diet induce susceptibility to metabolic and cardiovascular diseases in Solomon Islands
言語 en
作成者 Furusawa, Takuro

× Furusawa, Takuro

en Furusawa, Takuro

Naka, Izumi

× Naka, Izumi

en Naka, Izumi

Yamauchi, Taro

× Yamauchi, Taro

en Yamauchi, Taro

Natsuhara, Kazumi

× Natsuhara, Kazumi

en Natsuhara, Kazumi

Eddie, Ricky

× Eddie, Ricky

en Eddie, Ricky

Kimura, Ryosuke

× Kimura, Ryosuke

en Kimura, Ryosuke

Nakazawa, Minato

× Nakazawa, Minato

en Nakazawa, Minato

Ishida, Takafumi

× Ishida, Takafumi

en Ishida, Takafumi

Ohtsuka, Ryutaro

× Ohtsuka, Ryutaro

en Ohtsuka, Ryutaro

Ohashi, Jun

× Ohashi, Jun

en Ohashi, Jun

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution 4.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 https://creativecommons.org/licenses/by/4.0/
内容記述
内容記述タイプ Other
内容記述 The people of the Solomon Islands represent an Austronesian (AN)-speaking population’s adaptation to a humid tropical environment and subsistence of tuberous crops. Genome-wide association studies (GWASs) of other populations (e.g. the Human Genome Diversity Project [HGDP]) have suggested the existence of genotypes adaptive to ecoregion, diet, and subsistence, and that those genotypes are also associated with metabolic and cardiovascular diseases. Recently, the incidence of non-communicable diseases has been increasing in the Solomon Islands. In the present study, we explored the association of genotypes adaptive to a tropical environment and tuberous crop diet with metabolic and cardiovascular conditions in rural and urban AN-speaking Melanesian and Micronesian populations of the Solomon Islands. A total of 561 participants were genotyped for single nucleotide polymorphisms (SNPs) potentially associated with a tropical environment (rs174570 and rs2237892) and a tuberous crop diet (rs162036, rs185819, and rs2722425). The results showed that the allele frequencies of the Solomon Islands populations adopted patterns similar to those in populations from other hot, tropical areas with a tuberous crop diet in previous studies. Furthermore, rs162036, rs185819, rs2237892, and rs2722425 were all strongly associated with one or more metabolic and cardiovascular conditions. The derived allele of rs2722425 (i.e. rs2722425-G) was significantly associated with an elevated LDL level (P = 0.000264) even after the significance level was adjusted for multiple testing (i.e., α = 0.0005). Our results suggest that the inhabitants of the Solomon Islands exhibit the effects of the tropical environment and tuberous crop diet on their allele frequencies, and that their susceptibility to metabolic and cardiovascular diseases is therefore considered to be associated with their environment and diet.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Public Library of Science
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47014
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0172676
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0172676
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1932-6203
収録物名
言語 en
収録物名 PLoS ONE
書誌情報
巻 12, 号 3
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