ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "8e6cd9e3-1baf-4487-ac7a-daf87964966e"}, "_deposit": {"id": "2011160", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2011160"}, "status": "published"}, "_oai": {"id": "oai:u-ryukyu.repo.nii.ac.jp:02011160", "sets": ["1642838338003", "1642838407795"]}, "author_link": [], "item_1617186331708": {"attribute_name": "Title", "attribute_value_mlt": [{"subitem_1551255647225": "Testing the thrifty gene hypothesis : the Gly482Ser variant in PPARGC1Ais associated with BMI in Tongans", "subitem_1551255648112": "en"}]}, "item_1617186419668": {"attribute_name": "Creator", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Myles, Sean", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Lea, Rod A.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohashi, Jun", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Chambers, Geoff K.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Weiss, Joerg G.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hardouin, Emilie", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Engelken, Johannes", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Macartney-Coxson, Donia P.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Eccles, David A.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Naka, Izumi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kimura, Ryosuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Inaoka, Tsukasa", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Matsumura, Yasuhiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Stoneking, Mark", "creatorNameLang": "en"}]}]}, "item_1617186476635": {"attribute_name": "Access Rights", "attribute_value_mlt": [{"subitem_1522299639480": "open access", "subitem_1600958577026": "http://purl.org/coar/access_right/c_abf2"}]}, "item_1617186499011": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_1522650717957": "en", "subitem_1522651041219": "Creative Commons Attribution 2.0"}, {"subitem_1522650717957": "en", "subitem_1522650727486": "https://creativecommons.org/licenses/by/2.0/", "subitem_1522651041219": "https://creativecommons.org/licenses/by/2.0/"}]}, "item_1617186626617": {"attribute_name": "Description", "attribute_value_mlt": [{"subitem_description": "Background:The thrifty gene hypothesis posits that, in populations that experienced periods of feast and famine, natural selection favoured individuals carrying thrifty alleles that promote the storage of fat and energy. Polynesians likely experienced long periods of cold stress and starvation during their settlement of the Pacific and today have high rates of obesity and type 2 diabetes (T2DM), possibly due to past positive selection for thrifty alleles. Alternatively, T2DM risk alleles may simply have drifted to high frequency in Polynesians. To identify thrifty alleles in Polynesians, we previously examined evidence of positive selection on T2DM-associated SNPs and identified a T2DM risk allele at unusually high frequency in Polynesians. We suggested that the risk allele of the Gly482Ser variant in the PPARGC1A gene was driven to high frequency in Polynesians by positive selection and therefore possibly represented a thrifty allele in the Pacific.\\nMethods:Here we examine whether PPARGC1A is a thrifty gene in Pacific populations by testing for an association between Gly482Ser genotypes and BMI in two Pacific populations (Maori and Tongans) and by evaluating the frequency of the risk allele of the Gly482Ser variant in a sample of worldwide populations.\\nResults:We find that the Gly482Ser variant is associated with BMI in Tongans but not in Maori. In a sample of 58 populations worldwide, we also show that the 482Ser risk allele reaches its highest frequency in the Pacific.\\nConclusion:The association between Gly482Ser genotypes and BMI in Tongans together with the worldwide frequency distribution of the Gly482Ser risk allele suggests that PPARGC1A remains a candidate thrifty gene in Pacific populations.", "subitem_description_type": "Other"}, {"subitem_description": "\u8ad6\u6587", "subitem_description_type": "Other"}]}, "item_1617186643794": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_1522300295150": "en", "subitem_1522300316516": "BioMed Central"}]}, "item_1617186702042": {"attribute_name": "Language", "attribute_value_mlt": [{"subitem_1551255818386": "eng"}]}, "item_1617186783814": {"attribute_name": "Identifier", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/20.500.12000/47016"}]}, "item_1617186920753": {"attribute_name": "Source Identifier", "attribute_value_mlt": [{"subitem_1522646500366": "ISSN", "subitem_1522646572813": "1471-2350"}]}, "item_1617186941041": {"attribute_name": "Source Title", "attribute_value_mlt": [{"subitem_1522650068558": "en", "subitem_1522650091861": "BMC Medical Genetics"}]}, "item_1617187056579": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicVolumeNumber": "12"}]}, "item_1617258105262": {"attribute_name": "Resource Type", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_1617265215918": {"attribute_name": "Version Type", "attribute_value_mlt": [{"subitem_1522305645492": "VoR", "subitem_1600292170262": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_1617353299429": {"attribute_name": "Relation", "attribute_value_mlt": [{"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1186/1471-2350-12-10"}}, {"subitem_1522306287251": {"subitem_1522306382014": "DOI", "subitem_1522306436033": "https://doi.org/10.1186/1471-2350-12-10"}}]}, "item_1617605131499": {"attribute_name": "File", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "download_preview_message": "", "file_order": 0, "filename": "Myles2011_Article_TestingTheThriftyGeneHypothesi.pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "", "size": 0, "url": {"objectType": "fulltext", "url": "https://u-ryukyu.repo.nii.ac.jp/record/2011160/files/Myles2011_Article_TestingTheThriftyGeneHypothesi.pdf"}, "version_id": "ea11a9a1-bd21-4c93-847e-15499f1f854b"}]}, "item_title": "Testing the thrifty gene hypothesis : the Gly482Ser variant in PPARGC1Ais associated with BMI in Tongans", "item_type_id": "15", "owner": "1", "path": ["1642838338003", "1642838407795"], "permalink_uri": "http://hdl.handle.net/20.500.12000/47016", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-10-20"}, "publish_date": "2020-10-20", "publish_status": "0", "recid": "2011160", "relation": {}, "relation_version_is_last": true, "title": ["Testing the thrifty gene hypothesis : the Gly482Ser variant in PPARGC1Ais associated with BMI in Tongans"], "weko_shared_id": -1}
  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Testing the thrifty gene hypothesis : the Gly482Ser variant in PPARGC1Ais associated with BMI in Tongans

http://hdl.handle.net/20.500.12000/47016
http://hdl.handle.net/20.500.12000/47016
7d821064-076f-4b9e-bfba-9838ca8eefe3
名前 / ファイル ライセンス アクション
Myles2011_Article_TestingTheThriftyGeneHypothesi.pdf Myles2011_Article_TestingTheThriftyGeneHypothesi.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2020-10-20
タイトル
タイトル Testing the thrifty gene hypothesis : the Gly482Ser variant in PPARGC1Ais associated with BMI in Tongans
言語 en
作成者 Myles, Sean

× Myles, Sean

en Myles, Sean

Lea, Rod A.

× Lea, Rod A.

en Lea, Rod A.

Ohashi, Jun

× Ohashi, Jun

en Ohashi, Jun

Chambers, Geoff K.

× Chambers, Geoff K.

en Chambers, Geoff K.

Weiss, Joerg G.

× Weiss, Joerg G.

en Weiss, Joerg G.

Hardouin, Emilie

× Hardouin, Emilie

en Hardouin, Emilie

Engelken, Johannes

× Engelken, Johannes

en Engelken, Johannes

Macartney-Coxson, Donia P.

× Macartney-Coxson, Donia P.

en Macartney-Coxson, Donia P.

Eccles, David A.

× Eccles, David A.

en Eccles, David A.

Naka, Izumi

× Naka, Izumi

en Naka, Izumi

Kimura, Ryosuke

× Kimura, Ryosuke

en Kimura, Ryosuke

Inaoka, Tsukasa

× Inaoka, Tsukasa

en Inaoka, Tsukasa

Matsumura, Yasuhiro

× Matsumura, Yasuhiro

en Matsumura, Yasuhiro

Stoneking, Mark

× Stoneking, Mark

en Stoneking, Mark

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Creative Commons Attribution 2.0
言語 en
権利情報Resource https://creativecommons.org/licenses/by/2.0/
権利情報 https://creativecommons.org/licenses/by/2.0/
内容記述
内容記述タイプ Other
内容記述 Background:The thrifty gene hypothesis posits that, in populations that experienced periods of feast and famine, natural selection favoured individuals carrying thrifty alleles that promote the storage of fat and energy. Polynesians likely experienced long periods of cold stress and starvation during their settlement of the Pacific and today have high rates of obesity and type 2 diabetes (T2DM), possibly due to past positive selection for thrifty alleles. Alternatively, T2DM risk alleles may simply have drifted to high frequency in Polynesians. To identify thrifty alleles in Polynesians, we previously examined evidence of positive selection on T2DM-associated SNPs and identified a T2DM risk allele at unusually high frequency in Polynesians. We suggested that the risk allele of the Gly482Ser variant in the PPARGC1A gene was driven to high frequency in Polynesians by positive selection and therefore possibly represented a thrifty allele in the Pacific.\nMethods:Here we examine whether PPARGC1A is a thrifty gene in Pacific populations by testing for an association between Gly482Ser genotypes and BMI in two Pacific populations (Maori and Tongans) and by evaluating the frequency of the risk allele of the Gly482Ser variant in a sample of worldwide populations.\nResults:We find that the Gly482Ser variant is associated with BMI in Tongans but not in Maori. In a sample of 58 populations worldwide, we also show that the 482Ser risk allele reaches its highest frequency in the Pacific.\nConclusion:The association between Gly482Ser genotypes and BMI in Tongans together with the worldwide frequency distribution of the Gly482Ser risk allele suggests that PPARGC1A remains a candidate thrifty gene in Pacific populations.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 BioMed Central
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/47016
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/1471-2350-12-10
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/1471-2350-12-10
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1471-2350
収録物名
言語 en
収録物名 BMC Medical Genetics
書誌情報
巻 12
戻る
0
views
See details
Views

Versions

Ver.1 2022-02-01 06:36:23.852030
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON

確認


Powered by WEKO3


Powered by WEKO3